Intersection between Cognitive Impairment and Metabolic Alterations in the Molecular Mechanisms of Neurodegeneration
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 13517
Special Issue Editors
Interests: Alzheimer's disease; amyloidosis; neurodegenerative disorders, autophagy; apoptosis; mitochondrial dysfunction; oxidative stress; metabolic dysregulation; cerebral amyloid angiopathy; molecular chaperones; immunohistochemistry; neuroinflammation
Special Issues, Collections and Topics in MDPI journals
Interests: Alzheimer disease; neurodegenerative disorders; systemic and cerebral amyloidoses; aging; proteomics; post-translational modifications; blood-brain-barrier; amyloid; neurofibrillary tangles; cerebral amyloid angiopathy; cerebral hemorrhage; translational approaches; mouse models
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In recent decades, the incidence of neurodegenerative disorders, including Alzheimer’s and Parkinson’s diseases, vascular dementia, amyotrophic lateral sclerosis, and Huntington's disease, among others, has tremendously increased worldwide. Despite extensive research, the complex molecular mechanisms driving the pathogenesis of these disorders have not been fully elucidated, and disease-modifying therapeutic strategies remain to be discovered. Among the different pathways compromising the diverse group of neurodegenerative diseases, mounting evidence highlights a central role for mitochondrial detrimental changes, an altered cerebral glucose metabolism, and metabolic/bioenergetic shifts that frequently precede the cognitive abnormalities.
In parallel, cognitive dysfunction is being progressively recognized as a major comorbidity of metabolic diseases, particularly diabetes mellitus, and is often associated with metabolic stressors as the consumption of high-fat content diets and sedentary life styles. Experimental and epidemiological evidence suggests that the same molecular pathways implicated in insulin resistance, mitochondrial dysfunction, apoptosis, inflammation, and oxidative stress play a link between metabolism and cognitive dysfunction, suggesting causal relationships between different possible molecular etiologic factors.
This Special Issue aims to provide insight into the interplay between the multifaceted molecular pathways linking metabolic/bioenergetic alterations as significant contributors to the synaptic alterations, neuroinflammatory mechanisms, vascular dysfunction, and cognitive impairment associated with neurodegeneration. We welcome contributions in the form of original research articles, reviews and communications.
Dr. Agueda A. Rostagno
Prof. Dr. Jorge Ghiso
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cognitive impairment
- neurodegeneration
- vascular dysfunction
- neuroinflammatory
- cognitive abnormalities
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.
