Melatonin Receptors and Reproduction

Dear Colleagues,

Melatonin is a multifunctional molecule that influences many biological processes. There is a thriving field investigating its effects on reproduction. Melatonin relays photoperiodic cues, coordinating many physiological functions and acting as a paracrine signal and potent antioxidant. Whereas the pineal gland produces circulating melatonin that regulates the reproductive seasonality by modulating the hypothalamic–pituitary–gonadal axis, many authors have identified local functions in the reproductive system. Many tissues, including reproductive tissues, synthesize melatonin with paracrine activity. In the reproductive tract, melatonin also forms part of many secretions of reproductive interest, such as Sertoli cells secretions, seminal plasma, oviductal fluid, and follicular fluids.

The effects of melatonin, both circulatory and locally produced, have many potential functions in the reproductive tract and gamete functionality, from protective to regulatory. Melatonin also has a potent antioxidant effect, and many probed and putative receptors are present in these tissues, which could influence sperm chemotaxis, modulate its capacitation, and affect oocyte and embryo development. With so many effects, melatonin has attracted attention for its practical applications, with a great potential for contributing to artificial reproductive technologies.

Dr. Felipe Martinez-Pastor
Dr. Cristina Soriano-Úbeda
Guest Editors

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