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Bioactive Natural Products: Isolation, Structural Elucidation and Biological Assays, 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 30 August 2024 | Viewed by 1468

Special Issue Editor


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Guest Editor
1. Department of Chemical Sciences, University of Naples “Federico II”, Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126 Napoli, Italy
2. Institute of Sciences of Food Production, National Research Council, Via Amendola 122/O, 70125 Bari, Italy
Interests: Fungi; Bacterial; plant; metabolites; chemistry; spectroscopy; stereochemistry; biological activity; structure-activity relationships
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Special Issue Information

Dear Colleagues,

This Special Issue is the continuation of our Special Issue https://www.mdpi.com/journal/ijms/special_issues/Bioactive_
Structural
.

The natural sources had been always important to find new compounds with different chemical structure and biological activity with potential practical application in different fields. The source is essentially constituted by terrestrial and marine organisms and microorganism, and among them pathogen or endophytic fungi, bacteria, plant and marine organisms. Lichens, although lesser investigated, also are considered a source for natural compounds with original skeleton and biological activity. Thus the main aims of the special volume are the isolation and chemical and biological characterization of microbial, plant and lichen metabolites. Also article describing their derivatization for structure-activity relationships or mode of action studies and BIOFORMULATION are welcome. The results of mutidiciplinary research projects are preferred. The manuscript could be a scientific work or a reviewer.

Prof. Dr. Antonio Evidente
Guest Editor

Manuscript Submission Information

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Keywords

  • natural compounds
  • chemical characterization
  • biological charaterization
  • derivatization
  • structure-activity relationships
  • mode of action
  • bioformulation

Published Papers (1 paper)

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Research

17 pages, 2111 KiB  
Article
Madurastatins with Imidazolidinone Rings: Natural Products or Side-Reaction Products from Extraction Solvents?
by Mercedes Pérez-Bonilla, Marina Sánchez-Hidalgo, Ignacio González, Daniel Oves-Costales, Jesús Martín, José Murillo-Alba, José R. Tormo, Ahreum Cho, Soo-Young Byun, Joo-Hwan No, David Shum, Jean-Robert Ioset, Olga Genilloud and Fernando Reyes
Int. J. Mol. Sci. 2024, 25(1), 301; https://doi.org/10.3390/ijms25010301 - 25 Dec 2023
Viewed by 1077
Abstract
Madurastatins are a group of pentapeptides containing an oxazoline moiety, and, in a few cases, an imidazolidinone ring as an additional structural feature. In our search for new potential antiparasitic metabolites from natural sources, we studied the acetone extracts from a culture of [...] Read more.
Madurastatins are a group of pentapeptides containing an oxazoline moiety, and, in a few cases, an imidazolidinone ring as an additional structural feature. In our search for new potential antiparasitic metabolites from natural sources, we studied the acetone extracts from a culture of Actinomadura sp. CA-135719. The LC/HRMS analysis of this extract identified the presence of the known madurastatins C1 (1), D1 (4), and D2 (5) together with additional members of the family that were identified as the new madurastatins H2 (2) and 33-epi-D1 (3) after isolation and spectroscopic analysis. The planar structures of the new compounds were established by HRMS, ESI-qTOF-MS/MS, and 1D and 2D NMR data, and their absolute configuration was proposed using Marfey’s and bioinformatic analyses of the biosynthetic gene cluster (BGC). A revision of the absolute configuration of madurastatins D1 and D2 is proposed. Additionally, madurastatins containing imidazolidinone rings are proved to be artifacts originating during acetone extraction of the bacterial cultures. Full article
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