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Integrin Signaling and Human Pathologies 2021

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 4058

Special Issue Editors


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Guest Editor
RADOPT Team, Radiotherapy Optimising: From Molecular Signalling Pathways to Clinical Trials, Inserm U1037 Toulouse Cancer Research Center (CRCT) & IUCT 2 av. Hubert Curien, 31100 Toulouse, France
Interests: cell death; apoptosis; cellular differentiation; cellular and mitochondrial metabolism; cellular and mitochondrial homoeostasis; oxidative stress; cancer; cancer stem cells; glioma; radiotherapy and radioresistance
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Guest Editor
Centre de Recherches en Cancérologie de Toulouse - CRCT UMR1037 Inserm/Université Toulouse III-Paul Sabatier-ERL5294, CNRS 2 avenue Hubert Curien Oncopole entrée C CS 53717, 31037 Toulouse, France
Interests: invasion; RhoGTPases; integrins; stem cells, cancer; resistance to chemotherapy and radiotherapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Integrins are adhesion molecules that connect cells to ligands present in the extracellular matrix or to ligands expressed by blood cells. Upon binding to their ligands, integrins activate signaling pathways involved in key cellular processes like migration/invasion, cytoskeleton organization, survival, and angiogenesis. The dysregulation of integrins leads to various human pathologies: inflammatory diseases like atherosclerosis or inflammatory bowel disease; cancers; cardiovascular pathology; and respiratory diseases. This Special Issue of the International Journal of Molecular Sciences entitled “Integrin Signaling and Human Pathologies” will focus on the role of integrins in human pathologies. Authors are invited to submit manuscripts that study or review the role of these adhesion molecules in one of these human pathologies and that underline which integrin could be targeted in order to improve the treatment of these diseases.

Dr. Anthony Lemarié
Dr. Sylvie Monferran
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • integrin
  • glanzmann thrombasthenia
  • angiogenesis
  • cardiovascular disease
  • cancer
  • Crohn’s disease
  • ulcerative disease
  • multiple sclerosis
  • inflammatory bowel disease
  • respiratory diseases
  • eosinophilic esophagitis
  • age-related macular degeneration
  • epidermolysis bullosa
  • osteoporosis

Published Papers (1 paper)

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Review

17 pages, 1247 KiB  
Review
Integrin Signaling in the Central Nervous System in Animals and Human Brain Diseases
by Hiroko Ikeshima-Kataoka, Chikatoshi Sugimoto and Tatsuya Tsubokawa
Int. J. Mol. Sci. 2022, 23(3), 1435; https://doi.org/10.3390/ijms23031435 - 27 Jan 2022
Cited by 11 | Viewed by 3586
Abstract
The integrin family is involved in various biological functions, including cell proliferation, differentiation and migration, and also in the pathogenesis of disease. Integrins are multifunctional receptors that exist as heterodimers composed of α and β subunits and bind to various ligands, including extracellular [...] Read more.
The integrin family is involved in various biological functions, including cell proliferation, differentiation and migration, and also in the pathogenesis of disease. Integrins are multifunctional receptors that exist as heterodimers composed of α and β subunits and bind to various ligands, including extracellular matrix (ECM) proteins; they are found in many animals, not only vertebrates (e.g., mouse, rat, and teleost fish), but also invertebrates (e.g., planarian flatworm, fruit fly, nematodes, and cephalopods), which are used for research on genetics and social behaviors or as models for human diseases. In the present paper, we describe the results of a phylogenetic tree analysis of the integrin family among these species. We summarize integrin signaling in teleost fish, which serves as an excellent model for the study of regenerative systems and possesses the ability for replacing missing tissues, especially in the central nervous system, which has not been demonstrated in mammals. In addition, functions of astrocytes and reactive astrocytes, which contain neuroprotective subpopulations that act in concert with the ECM proteins tenascin C and osteopontin via integrin are also reviewed. Drug development research using integrin as a therapeutic target could result in breakthroughs for the treatment of neurodegenerative diseases and brain injury in mammals. Full article
(This article belongs to the Special Issue Integrin Signaling and Human Pathologies 2021)
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