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Biomedicines
Special Issues
Xenotransplantation: Targeting Acute Vascular Rejection and Endothelial Activation
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Xenotransplantation: Targeting Acute Vascular Rejection and Endothelial Activation

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 713

Special Issue Editor

Dr. Konrad Fischer

E-Mail Website
Guest Editor
Chair of Livestock Biotechnology, Technical University of Munich, Freising, Germany
Interests: xenotransplantation; translational pig models; livestock engineering; immunology; allergy development

Special Issue Information

Dear Colleagues,

Acute vascular rejection (AVR) still presents a major hurdle to long-term xenograft acceptance. Although several transgene combinations and knockouts have been described, xenografts are still undergoing AVR. New insights into innate and adaptive immune responses as well as detailed characterizations of signaling pathways are necessary to further optimize the pigs and protect the xenografts. In this Special Issue, we focus on the role of the endothelium during AVR, including the endothelial glycocalyx and underlying signaling pathways, and investigate new means of overcoming blood coagulation mechanisms and thrombotic microangiopathy (TMA).

Dr. Konrad Fischer
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • endothelial activation
  • endothelial protection
  • thrombotic microangiopathy
  • glycocalyx
  • acute vascular rejection

Published Papers (1 paper)

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Research

15 pages, 1351 KiB  
Article
The Endothelial Glycocalyx in Pig-to-Baboon Cardiac Xenotransplantation—First Insights
by Martin Bender, Jan-Michael Abicht, Bruno Reichart, Maria Leuschen, Felicia Wall, Julia Radan, Elisabeth Neumann, Maren Mokelke, Ines Buttgereit, Sebastian Michel, Reinhard Ellgass, Katja Gieseke, Stig Steen, Audrius Paskevicius, Joachim Denner, Antonia W. Godehardt, Ralf R. Tönjes, Christian Hagl, David Ayares, Eckhard Wolf, Michael Schmoeckel, Paolo Brenner, Martin B. Müller and Matthias Länginadd Show full author list remove Hide full author list
Biomedicines 2024, 12(6), 1336; https://doi.org/10.3390/biomedicines12061336 - 16 Jun 2024
Viewed by 438
Abstract
Cardiac xenotransplantation has seen remarkable success in recent years and is emerging as the most promising alternative to human cardiac allotransplantation. Despite these achievements, acute vascular rejection still presents a challenge for long-term xenograft acceptance and new insights into innate and adaptive immune [...] Read more.
Cardiac xenotransplantation has seen remarkable success in recent years and is emerging as the most promising alternative to human cardiac allotransplantation. Despite these achievements, acute vascular rejection still presents a challenge for long-term xenograft acceptance and new insights into innate and adaptive immune responses as well as detailed characterizations of signaling pathways are necessary. In allotransplantation, endothelial cells and their sugar-rich surface—the endothelial glycocalyx—are known to influence organ rejection. In xenotransplantation, however, only in vitro data exist on the role of the endothelial glycocalyx so far. Thus, in the current study, we analyzed the changes of the endothelial glycocalyx components hyaluronan, heparan sulfate and syndecan-1 after pig-to-baboon cardiac xenotransplantations in the perioperative (n = 4) and postoperative (n = 5) periods. These analyses provide first insights into changes of the endothelial glycocalyx after pig-to-baboon cardiac xenotransplantation and show that damage to the endothelial glycocalyx seems to be comparable or even less pronounced than in similar human settings when current strategies of cardiac xenotransplantation are applied. At the same time, data from the experiments where current strategies, like non-ischemic preservation, growth inhibition or porcine cytomegalovirus (a porcine roseolovirus (PCMV/PRV)) elimination could not be applied indicate that damage of the endothelial glycocalyx also plays an important role in cardiac xenotransplantation. Full article
(This article belongs to the Special Issue Xenotransplantation: Targeting Acute Vascular Rejection and Endothelial Activation)
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