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Special Issue "Fibrosis-Related lncRNA"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 31 March 2020.

Special Issue Editors

Dr. Kwan-Kyu Park
E-Mail Website
Guest Editor
Catholic University of Daegu, Daegu, South Korea
Interests: lncRNA; fibrosis; inflammation; biologic marker; therapeutic target
Dr. Sarath Chandra Janga
E-Mail Website
Guest Editor
Indiana University-Purdue University Indianapolis, Indianapolis, United States
Interests: Transcriptomics; Post-transcriptional regulation; RNA-binding proteins; Epitranscriptomics; Gene regulatory networks; Systems biology; Single Molecule Sequencing; RNA structure and interactions

Special Issue Information

Dear Colleagues, 

It is known that less than 2% of the transcribed genome encodes protein-coding RNA. Most noncoding transcripts are composed of more than 200 base pairs and constitute a group of long noncoding RNA (lncRNA). Many studies have shown that lncRNAs play key roles in a variety of biological processes, such as proliferation and apoptosis, through complex mechanisms. Recently, lncRNA has become a potential hot topic in diagnosing human disease and as biological markers in predicting the prognosis and treatment in cancer. They also play an important role in the development of fibrosis-related diseases in various organs including the liver, heart, lung, and kidney. Fibrosis is the excess deposition of extracellular matrix components, which can occur in multiple organs, and ultimately leads to organ failure. Although lncRNAs are important players in the initiation and progression of many pathological processes, the role of lncRNAs in organ fibrosis still remains largely undefined. LncRNA is also highly disease- and tissue-specific, and they could be an ideal therapeutic target for developing treatment against fibrosis-related disease.

This open-access Special Issue will bring together original research and review articles on the functions of lncRNAs in various fibrotic diseases of the liver, heart, kidney, lung, and peritoneum. Furthermore, this Special Issue systematically highlights the roles of lncRNAs and technical developments on the use of lncRNAs as diagnostic markers and therapeutic targets for their clinical use in human fibrotic diseases.

Dr. Kwan-Kyu Park
Dr. Sarath Chandra Janga
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • lncRNA
  • fibrosis
  • inflammation
  • biologic marker
  • therapeutic target

Published Papers (1 paper)

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Open AccessReview
Idiopathic Pulmonary Fibrosis: Pathogenesis and the Emerging Role of Long Non-Coding RNAs
Int. J. Mol. Sci. 2020, 21(2), 524; https://doi.org/10.3390/ijms21020524 - 14 Jan 2020
Idiopathic pulmonary fibrosis (IPF) is a progressive chronic disease characterized by excessing scarring of the lungs leading to irreversible decline in lung function. The aetiology and pathogenesis of the disease are still unclear, although lung fibroblast and epithelial cell activation, as well as [...] Read more.
Idiopathic pulmonary fibrosis (IPF) is a progressive chronic disease characterized by excessing scarring of the lungs leading to irreversible decline in lung function. The aetiology and pathogenesis of the disease are still unclear, although lung fibroblast and epithelial cell activation, as well as the secretion of fibrotic and inflammatory mediators, have been strongly associated with the development and progression of IPF. Significantly, long non-coding RNAs (lncRNAs) are emerging as modulators of multiple biological processes, although their function and mechanism of action in IPF is poorly understood. LncRNAs have been shown to be important regulators of several diseases and their aberrant expression has been linked to the pathophysiology of fibrosis including IPF. This review will provide an overview of this emerging role of lncRNAs in the development of IPF. Full article
(This article belongs to the Special Issue Fibrosis-Related lncRNA)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Therapeutic effect of synthetic lncRNA for the regulation of STAT3 expression in an animal model of renal fibrosis
Authors: Kwan-Kyu Park; et al.

Title: LncRNAs in renal fibrosis: Functional role and pathogenesis
Authors: Kwan-Kyu Park; et al.

Title: TGF-beta and lncRNAs in renal fibrosis
Authors: Hui Yao Lan; et al.

Title: The role of long non-coding RNAs in the pathogenesis of idiopathic pulmonary fibrosis
Authors: Marina Hadjicharalambous; et al.

Title: Long non-coding RNAs in Parkinson’s disease: a systematic review
Authors: Jin-Woo Park; et al.

Title: The role of long Non-coding RNA involve in various fibrosis diseases
Authors: Kwang-Huei Lin; et al.

Title: Logical rules analysis of cancer-related lncRNAs based on gene ontology and KEGG pathways using machine learning method
Authors: Yudong Cai; et al.

Title: The role of LncRNA in the course of chronic hepatitis to hepatocelluar carinoma
Authors: S J Lee; et al.

Title: The roles and mechanism of lncRNA in liver fibrosis
Authors: Deying Yang; et al.

Title: The Biology of PVT1
Authors: Olorunseun O. Ogunwobi; et al.

Title: Aberrant lncRNA expression profile in fibrosis of skin and internal organs in patients with systemic sclerosis
Authors: Chia-Li Yu; et al.

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