Special Issue "Extracellular Vesicles in Reproduction"
Deadline for manuscript submissions: 31 October 2020.
Interests: andrology; reproductive biotechnologies; gamete interactions
Interests: spermatozoa; seminal plasma; extracellular vesicles; proteomics; cytokines
Interests: animal reproduction
The homeostasis of an individual depends basically on the ability of the differences cells, systems, and body compartments to interact via complex processes of communication. Among these, we know of humoral, hormonal, and nervous processes, and from the initial findings from the 1960s to today we include the role of cell-derived vesicles that communicate cell-to-cell beyond intercellular organized contacts, and vesicles that circulate in intercellular matrixes and secretions, lymph fluid, or blood to gain contact and mediate stimulus and responses at long distances from the originating cell. These extracellular vesicles (EVs) are further distinguished as exosomes, microvesicles, or apoptotic bodies, the latter being mostly related to cell death and nearby, local contacts, while the first names are related to systemic cell communication. All EVs have in common that they carry loads of molecules (proteins, peptides, lipids, carbohydrates, and nucleic acids) or even organelles (apoptotic bodies) with the capacity of respond to stimuli, intervene in metabolic pathways, or influence gene expression. Often having the characteristics of the originating cell, they serve as biomarkers of origin and of function beyond a specific target. The reproductive system is able to communicate via EVs, with some EVs playing important roles in spermatogenesis, sperm maturation, oogenesis, and embryogenesis, as well as influencing other systems, including the immune system to modulate immune responses, during the development and function of hemi-allogeneic organs as the placenta or the survival of the foetus throughout pregnancy.
This Issue of IJMS is focused on "Extracellular Vesicles in Reproduction”. The Issue welcomes papers covering EVs characterization, quantification, disclosure of their load, and elucidation of their biogenesis and roles when modulating reproductive events. The Issue welcomes novel research, certainly of comparative aspects but also of methodological papers, as well as insightful, critical reviews in these areas.
Prof. Heriberto Rodriguez-Martinez
Prof. Jordi Roca
Prof. Emilio A. Martinez
Manuscript Submission Information
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- extracellular vesicles
- apoptotic bodies
- reproductive processes
- sperm maturation
- seminal plasma
- sperm capacitation
- immune modulation
- immune tolerance