Special Issue "Epigenetics of Diabetes and Related Complications"
Deadline for manuscript submissions: closed (30 November 2019) | Viewed by 18806
Interests: signal transduction; glucose metabolism; type 2 diabetes; insulin resistance; beta-cell function; glucotoxicity; epigenetic of type 2 diabetes; diabetes and cognitive diseases; diabetes and cancer
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Interests: type 2 Diabetes; diabetes epigenetics; genetic of T2D; insulin action and signalling; insulin resistance; insulin secretion
A growing body of evidence suggests that dynamic alterations in the epigenome (i.e., DNA methylation, histone marks, and non-coding RNAs) play a causative role in the activation of the molecular events responsible for diabetes progression and associated complications. These events can be induced by metabolic changes, such as hyperglycaemia, and can be responsible for a long-lasting impairment of vascular and cardiac function, even after intensive glycemic control. Indeed, diabetes complications can be affected by glucose levels that were experienced years earlier, a phenomenon called metabolic memory. Notably, the adverse epigenetic profile acquired over the life course can be transmitted to the offspring, and may contribute to early cardiovascular phenotypes in younger generations.
Unveiling the epigenetic landscape in diabetic subjects and people at risk of developing diabetes is beneficial to provide tools for personalized epigenetic-based therapies.
The aim of this Special Issue is to provide a collection of original and review articles aimed at advancing the current knowledge of the epigenetics of diabetes and its implications in classic diabetes complications and co-morbidities.
Assoc. Dr. Claudia Miele
Prof. Francesco Beguinot
Manuscript Submission Information
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- Diabetes mellitus
- Glycation stress
- Histone marks
- Metabolic memory
- Vascular complications
- Cognitive disease
- Cancer risk