Epigenetic Mechanisms of Neurodegenerative Diseases

Dear Colleagues,

Over the past few years, accumulating evidence has suggested that epigenetic mechanisms, such as DNA methylation, histone post-translational modifications, and miRNAs, can play an important role in a variety of processes related to aging, including neurodegenerative diseases. Epigenetic mechanisms are finely regulated and influenced by multiple environmental factors throughout the lifespan. Contrary to genetic alterations, epigenetic modifications are reversible and may therefore be a promising target for new therapeutic strategies. 

Neurodegenerative diseases, such as Alzheimer’s disease, Huntington’s disease, multiple sclerosis, and amyotrophic lateral sclerosis, are debilitating and incurable conditions affecting millions of people worldwide. Although the etiopathogenesis of neurodegenerative diseases is not well known yet, they share some common features, including transcriptional dysregulation. However, the mechanisms underlying the epigenetic alterations in the development of neurodegenerative diseases are still poorly understood.

In this Special Issue, we aim at collecting original as well as review papers that provide state-of-the-art insight into the role of epigenetic mechanisms in the context of neurodegenerative diseases. Papers analyzing environmental factors (diet, stress, pollution, pathogen infection, exercise, etc.) affecting epigenetic mechanisms and neurodegenerative diseases will be particularly welcome.

Dr. Alessandro Ieraci
Guest Editor

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