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Lymphatic System in Vascular Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 30 July 2024 | Viewed by 1130

Special Issue Editors


E-Mail Website
Guest Editor
Department of Angiology, Hypertension and Diabetology, Wroclaw Medical University, 50-367 Wrocław, Poland
Interests: lymphatic system

E-Mail Website
Guest Editor
Department of Angiology, Hypertension and Diabetology, Wroclaw Medical University, 50-367 Wrocław, Poland
Interests: diet

Special Issue Information

Dear Colleagues,

Many recent studies have confirmed that the lymphatic system plays an essential role in the pathogenesis of vascular diseases, including atherosclerosis, chronic venous insufficiency, and arterial hypertension. However, the relationship between the lymphatic and vascular systems has not been thoroughly explored. Only a better understanding of this relationship will open up new possibilities for therapeutic interventions in vascular diseases.

This Special Issue aims to expand our knowledge on the physiological and pathological role of the lymphatic system in vascular diseases.

We are pleased to invite you to share the results of your current research on the relationship between the lymphatic system and vascular diseases. This Special Issue is intended to consist of basic, translational, clinical, original, and review articles.

Potential areas of interest include, but are not limited to:

  • Atherosclerosis;
  • Vasculitis;
  • Vascular malformations;
  • Hypertension;
  • Chronic venous insufficiency;
  • The function of the lymphatic system in the vascular system of many organ systems, such as the heart, lungs, liver, kidneys, and brain.

Dr. Angelika Chachaj
Prof. Dr. Andrzej Szuba
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lymphatic system
  • vascular disease
  • vascular biology
  • microcirculation
  • atherosclerosis
  • blood pressure
  • chronic venous insufficiency
  • peripheral arterial disease
  • lipid metabolism
  • reverse cholesterol transport
  • vasculitis
  • inflammation
  • angiogenesis
  • lymphangiogenesis
  • vascular malformations

Published Papers (1 paper)

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Review

17 pages, 886 KiB  
Review
The Role of Inflammation in Lymphedema: A Narrative Review of Pathogenesis and Opportunities for Therapeutic Intervention
by Catharine Bowman and Stanley G. Rockson
Int. J. Mol. Sci. 2024, 25(7), 3907; https://doi.org/10.3390/ijms25073907 - 31 Mar 2024
Viewed by 859
Abstract
Lymphedema is a chronic and progressive disease of the lymphatic system characterized by inflammation, increased adipose deposition, and tissue fibrosis. Despite early hypotheses identifying lymphedema as a disease of mechanical lymphatic disruption alone, the progressive inflammatory nature underlying this condition is now well-established. [...] Read more.
Lymphedema is a chronic and progressive disease of the lymphatic system characterized by inflammation, increased adipose deposition, and tissue fibrosis. Despite early hypotheses identifying lymphedema as a disease of mechanical lymphatic disruption alone, the progressive inflammatory nature underlying this condition is now well-established. In this review, we provide an overview of the various inflammatory mechanisms that characterize lymphedema development and progression. These mechanisms contribute to the acute and chronic phases of lymphedema, which manifest clinically as inflammation, fibrosis, and adiposity. Furthermore, we highlight the interplay between current therapeutic modalities and the underlying inflammatory microenvironment, as well as opportunities for future therapeutic development. Full article
(This article belongs to the Special Issue Lymphatic System in Vascular Disease)
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