Special Issue "Diacylglycerol Kinases in Signal Transduction"
Deadline for manuscript submissions: closed (28 February 2021).
Interests: diacylglycerol kinase; lipid signaling; receptor signal transduction; apoptosis; T cell receptor
The phosphorylation of diacylglycerol to phosphatidic acid tunes the level and localization of two key signaling lipids. Thus, diacylglycerol kinases constitute a critical node in signal transduction and a fascinating target for novel therapies. In particular, the increasing number of proteins that are known to be regulated either by diacylglycerol or by phosphatidic acid maintain the great interest in those enzymes. Despite its widespread patterns of expression, the biological function of diacylglycerol kinase has mainly only been explored in the immune and nervous system, while translational approaches have focused on cell transformation and cancer.
By including both research articles and reviews, this Special Issue aims to capture the state of art of the research on the role of diacylglycerol kinase in signaling and phospholipid metabolism. The main focus will be on progressive advancements in the understanding of diacylglycerol kinase regulation and the biological role in different cellular contexts as well as contribution to disease development. Of particular interest are the recent efforts aiming to capitalize the available knowledge in terms of therapeutic advancements using pharmacological inhibitors and genetic tools in spite of the incomplete knowledge of diacylglycerol kinase structure.
Dr. Gianluca Baldanzi
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- lipid metabolism
- signal transduction
- genetic models
- immune function