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New Era of Diacylglycerol Kinase, Phosphatidic Acid and Phosphatidic Acid-Binding Protein
Review

Beyond Lipid Signaling: Pleiotropic Effects of Diacylglycerol Kinases in Cellular Signaling

1
Department of Orthopedic Surgery, Gil Medical Center, College of Medicine, Gachon University, Incheon 21565, Korea
2
Department of Biochemistry, College of Medicine, Gachon University, Incheon 21999, Korea
3
Department of Physiology, College of Medicine, Gachon University, Incheon 21999, Korea
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(18), 6861; https://doi.org/10.3390/ijms21186861
Received: 26 August 2020 / Revised: 11 September 2020 / Accepted: 16 September 2020 / Published: 18 September 2020
(This article belongs to the Special Issue Diacylglycerol Kinases in Signal Transduction)
The diacylglycerol kinase family, which can attenuate diacylglycerol signaling and activate phosphatidic acid signaling, regulates various signaling transductions in the mammalian cells. Studies on the regulation of diacylglycerol and phosphatidic acid levels by various enzymes, the identification and characterization of various diacylglycerol and phosphatidic acid-regulated proteins, and the overlap of different diacylglycerol and phosphatidic acid metabolic and signaling processes have revealed the complex and non-redundant roles of diacylglycerol kinases in regulating multiple biochemical and biological networks. In this review article, we summarized recent progress in the complex and non-redundant roles of diacylglycerol kinases, which is expected to aid in restoring dysregulated biochemical and biological networks in various pathological conditions at the bed side. View Full-Text
Keywords: diacylglycerol kinase; diacylglycerol; phosphatidic acid; tissue microenvironment; tumor microenvironment; lipid signaling diacylglycerol kinase; diacylglycerol; phosphatidic acid; tissue microenvironment; tumor microenvironment; lipid signaling
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MDPI and ACS Style

Sim, J.A.; Kim, J.; Yang, D. Beyond Lipid Signaling: Pleiotropic Effects of Diacylglycerol Kinases in Cellular Signaling. Int. J. Mol. Sci. 2020, 21, 6861. https://doi.org/10.3390/ijms21186861

AMA Style

Sim JA, Kim J, Yang D. Beyond Lipid Signaling: Pleiotropic Effects of Diacylglycerol Kinases in Cellular Signaling. International Journal of Molecular Sciences. 2020; 21(18):6861. https://doi.org/10.3390/ijms21186861

Chicago/Turabian Style

Sim, Jae A., Jaehong Kim, and Dongki Yang. 2020. "Beyond Lipid Signaling: Pleiotropic Effects of Diacylglycerol Kinases in Cellular Signaling" International Journal of Molecular Sciences 21, no. 18: 6861. https://doi.org/10.3390/ijms21186861

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