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Subcellular Localization Relevance and Cancer-Associated Mechanisms of Diacylglycerol Kinases

1
Cellular Signalling Laboratory, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
2
Center for the Diagnosis and Treatment of Hypothalamic-Pituitary Diseases-Pituitary Unit, IRCCS Istituto delle Scienze Neurologiche di Bologna (Institute of Neurological Sciences of Bologna), 40126 Bologna, Italy
3
Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, 40126 Bologna, Italy
4
Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC 27858, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(15), 5297; https://doi.org/10.3390/ijms21155297
Received: 24 June 2020 / Revised: 21 July 2020 / Accepted: 24 July 2020 / Published: 26 July 2020
(This article belongs to the Special Issue Diacylglycerol Kinases in Signal Transduction)
An increasing number of reports suggests a significant involvement of the phosphoinositide (PI) cycle in cancer development and progression. Diacylglycerol kinases (DGKs) are very active in the PI cycle. They are a family of ten members that convert diacylglycerol (DAG) into phosphatidic acid (PA), two-second messengers with versatile cellular functions. Notably, some DGK isoforms, such as DGKα, have been reported to possess promising therapeutic potential in cancer therapy. However, further studies are needed in order to better comprehend their involvement in cancer. In this review, we highlight that DGKs are an essential component of the PI cycle that localize within several subcellular compartments, including the nucleus and plasma membrane, together with their PI substrates and that they are involved in mediating major cancer cell mechanisms such as growth and metastasis. DGKs control cancer cell survival, proliferation, and angiogenesis by regulating Akt/mTOR and MAPK/ERK pathways. In addition, some DGKs control cancer cell migration by regulating the activities of the Rho GTPases Rac1 and RhoA. View Full-Text
Keywords: diacylglycerol; phosphoinositide; PI3K/Akt/mTOR; DGKs; lipids; cancer diacylglycerol; phosphoinositide; PI3K/Akt/mTOR; DGKs; lipids; cancer
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MDPI and ACS Style

Fazio, A.; Owusu Obeng, E.; Rusciano, I.; Marvi, M.V.; Zoli, M.; Mongiorgi, S.; Ramazzotti, G.; Follo, M.Y.; McCubrey, J.A.; Cocco, L.; Manzoli, L.; Ratti, S. Subcellular Localization Relevance and Cancer-Associated Mechanisms of Diacylglycerol Kinases. Int. J. Mol. Sci. 2020, 21, 5297. https://doi.org/10.3390/ijms21155297

AMA Style

Fazio A, Owusu Obeng E, Rusciano I, Marvi MV, Zoli M, Mongiorgi S, Ramazzotti G, Follo MY, McCubrey JA, Cocco L, Manzoli L, Ratti S. Subcellular Localization Relevance and Cancer-Associated Mechanisms of Diacylglycerol Kinases. International Journal of Molecular Sciences. 2020; 21(15):5297. https://doi.org/10.3390/ijms21155297

Chicago/Turabian Style

Fazio, Antonietta, Eric Owusu Obeng, Isabella Rusciano, Maria V. Marvi, Matteo Zoli, Sara Mongiorgi, Giulia Ramazzotti, Matilde Y. Follo, James A. McCubrey, Lucio Cocco, Lucia Manzoli, and Stefano Ratti. 2020. "Subcellular Localization Relevance and Cancer-Associated Mechanisms of Diacylglycerol Kinases" International Journal of Molecular Sciences 21, no. 15: 5297. https://doi.org/10.3390/ijms21155297

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