Genetic and Epigenetic Determinants of Age-Related Traits: New Challenges and Insights

Dear Colleagues,

We are assisting in the increased life expectancy of the population, parallel to a significant rise in the prevalence of chronic diseases. Over the last decades, genetic and epigenetic alterations were found to underlie changes occurring later in life, including susceptibility to diseases. More recently, multi-omics approaches have significantly steered biomedical research, helping to untangle the complexity of the biological and molecular factors implicated in age-related traits. While all of these foregoing advances are significant, there are still many aspects of this topic, i.e., the combined effects of genetic, epigenetic, and environmental influences, that need to be further investigated.

The aims of this Special Issue are to summarize the current knowledge in the field, suggest new directions for future research, both in humans and model systems, and aim to assess the individual risk of age-related diseases, a topic which will be at the forefront of aging research in the coming decade.

Authors may submit research articles, reviews, and short communications that cover the aforementioned areas, particularly those exploring the interfaces among genetics, epigenetics, and the environment as determinants of age-related traits.

Prof. Dr. Giuseppina Rose
Dr. Paolina Crocco
Dr. Serena Dato
Guest Editors

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