Special Issue "DNA Injury and Repair Systems"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 July 2017).
Interests: Oxidative stress-induced DNA damage and its repair in cardiometabolic and cancer diseases
Special Issues and Collections in MDPI journals
Special Issue in International Journal of Molecular Sciences: DNA Damage and Repair in Degenerative Diseases 2014
Special Issue in International Journal of Molecular Sciences: DNA Damage and Repair in Degenerative Diseases 2016
Special Issue in International Journal of Molecular Sciences: The Role of Oxidative Stress Biomarkers in Translational Clinical Research: From the Bench to Bedside
Special Issue in International Journal of Molecular Sciences: DNA Damage and Repair in Biology and Medicine
The integrity of the structure and composition of nucleic acids is a fundamental requirement, not only to ensure fidelity in the transmission of the genetic message, but also to preserve the metabolic regulation and physiological functions of living organisms. However, the genetic material is exposed to multiple exogenous and endogenous sources that modify its structure through different interaction mechanisms. Some of these modifications play regulatory roles necessary for the control of cell growth and differentiation while others are detrimental for their survival.
Ionizing, neutron or UV radiations, the interaction with chemical agents and prooxidants, in addition to many other environmental factors, are major sources of DNA lesions. Some of these agents have proved to be very useful in the treatment of tumor diseases. However, the modification and damage to DNA is a well-known mechanism of spontaneous mutations leading to sporadic cancer.
It is deduced that the cells have evolved thanks to their ability to escape from the harmful impacts on its DNA structure trying to maintain a balance between the processes of regulatory modifications and those that endanger their viability and biological functions. This ability lies on the DNA repair systems, which have been conserved along the phylogenetic scale. DNA repair is of vital importance and its effectiveness is ensured by a complex process of molecular signaling and interactions involving multiple and sophisticated groups of proteins including transcriptional factors, and tumor suppressor genes working in an orchestrated manner with a specific repair enzymes.
The repair of the genetic material encompasses each and every one of its different damaging forms. Inefficiency of one or more of these repair proteins have been related with the abnormal regulation of apoptosis and cellular senescence, therefore contributing to the development of degenerative diseases.
In this Special Issue, special attention will be focused on the different agents and mechanisms responsible for the modification of genetic material, as well as repair systems as essential biological factors for the maintenance of cell homeostasis.
Prof. Guillermo T. Sáez
Manuscript Submission Information
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- DNA modification and damage
- oxidative damage
- DNA repair mechanisms