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Int. J. Mol. Sci. 2017, 18(12), 2611; https://doi.org/10.3390/ijms18122611

Around and beyond 53BP1 Nuclear Bodies

Toxalim (Research Centre in Food Toxicology), Université de Toulouse, INRA, ENVT, INP-Purpan, UPS, 31027 Toulouse, France
These authors contributed equally to this work.
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Received: 3 November 2017 / Revised: 27 November 2017 / Accepted: 1 December 2017 / Published: 5 December 2017
(This article belongs to the Special Issue DNA Injury and Repair Systems)
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Abstract

Within the nucleus, sub-nuclear domains define territories where specific functions occur. Nuclear bodies (NBs) are dynamic structures that concentrate nuclear factors and that can be observed microscopically. Recently, NBs containing the p53 binding protein 1 (53BP1), a key component of the DNA damage response, were defined. Interestingly, 53BP1 NBs are visualized during G1 phase, in daughter cells, while DNA damage was generated in mother cells and not properly processed. Unlike most NBs involved in transcriptional processes, replication has proven to be key for 53BP1 NBs, with replication stress leading to the formation of these large chromatin domains in daughter cells. In this review, we expose the composition and organization of 53BP1 NBs and focus on recent findings regarding their regulation and dynamics. We then concentrate on the importance of the replication stress, examine the relation of 53BP1 NBs with DNA damage and discuss their dysfunction. View Full-Text
Keywords: 53BP1; nuclear bodies; DNA damage; replication stress; common fragile sites; genetic instability; cancer 53BP1; nuclear bodies; DNA damage; replication stress; common fragile sites; genetic instability; cancer
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Fernandez-Vidal, A.; Vignard, J.; Mirey, G. Around and beyond 53BP1 Nuclear Bodies. Int. J. Mol. Sci. 2017, 18, 2611.

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