FANCD2 and DNA Damage
1
Cancer Biology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA
2
Graduate Program of Molecular Biosciences and Bioengineering, University of Hawaii, Honolulu, HI 96813, USA
3
Department of Laboratory Medicine and Pathology, Mayo Clinic Foundation, Rochester, MN 55905, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2017, 18(8), 1804; https://doi.org/10.3390/ijms18081804
Received: 31 July 2017 / Revised: 8 August 2017 / Accepted: 12 August 2017 / Published: 19 August 2017
(This article belongs to the Special Issue DNA Injury and Repair Systems)
Investigators have dedicated considerable effort to understanding the molecular basis underlying Fanconi Anemia (FA), a rare human genetic disease featuring an extremely high incidence of cancer and many congenital defects. Among those studies, FA group D2 protein (FANCD2) has emerged as the focal point of FA signaling and plays crucial roles in multiple aspects of cellular life, especially in the cellular responses to DNA damage. Here, we discuss the recent and relevant studies to provide an updated review on the roles of FANCD2 in the DNA damage response.
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Keywords:
Fanconi anemia; FANCD2; DNA damage repair; checkpoint; cancer and aging
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MDPI and ACS Style
Nepal, M.; Che, R.; Ma, C.; Zhang, J.; Fei, P. FANCD2 and DNA Damage. Int. J. Mol. Sci. 2017, 18, 1804.
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