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Special Issue "Role of Dendritic Cells in Inflammation"
Deadline for manuscript submissions: 30 November 2019.
In 1973, a new type of cell was described. These cells, only partially resembling macrophages, were characterized by dendrite-like projections and for this reason they were named dendritic cells (DCs). The first functional analysis revealed them as the most potent antigen-presenting cells, able to capture, process, and present antigens to initiate the adaptive immune response. Soon after, Steinman was beginning to understand that the role of DCs was not only related with the initiation of the aggressive immune response, but also with the immunological tolerance: “The function of these presenting cells in immunologic tolerance is just beginning to be studied.”
It is now clear that DCs’ biology and response is extremely diverse, as results of the DC subpopulation considered, the tissue analyzed, and even the same subpopulation in the same tissue could act differently in response to environmental factors.
With the present Special Issue, we aim to elucidate DCs’ role during inflammation, host defense, inflammatory suppression, and potential contribution to dysregulated immune response leading to chronic inflammatory syndromes.
DCs could be biological targets of future precision therapies, but the complex biology of these cells requires detailed knowledge of their biology. This Special Issue will consider reviews and original manuscripts that highlight DCs’ response in extreme conditions: chronic inflammation, infection, auto-immune response, and undesired induction of tolerance.
Dr. Marcello Chieppa
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- dendritic cells
- immunological tolerance
- chronic inflammation
- auto-immune response
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Production of IFNβ by Conventional Dendritic Cells after Stimulation with Viral Compounds is Associated with Aggravation of Polymicrobial Sepsis
Author: Stefanie Susanne Scheu