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Distinct Subcellular Compartments of Dendritic Cells Used for Cross-Presentation

Laboratory of Physiological Chemistry, Faculty of Pharmacy, Takasaki University of Health and Welfare, Takasaki, Gunma 370-0033, Japan
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Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(22), 5606; https://doi.org/10.3390/ijms20225606 (registering DOI)
Received: 26 August 2019 / Revised: 29 October 2019 / Accepted: 6 November 2019 / Published: 9 November 2019
(This article belongs to the Special Issue Role of Dendritic Cells in Inflammation)
Dendritic cells (DCs) present exogenous protein-derived peptides on major histocompatibility complex class I molecules to prime naïve CD8+ T cells. This DC specific ability, called cross-presentation (CP), is important for the activation of cell-mediated immunity and the induction of self-tolerance. Recent research revealed that endoplasmic reticulum-associated degradation (ERAD), which was first identified as a part of the unfolded protein response—a quality control system in the ER—plays a pivotal role in the processing of exogenous proteins in CP. Moreover, DCs express a variety of immuno-modulatory molecules and cytokines to regulate T cell activation in response to the environment. Although both CP and immuno-modulation are indispensable, contrasting ER conditions are required for their correct activity. Since ERAD substrates are unfolded proteins, their accumulation may result in ER stress, impaired cell homeostasis, and eventually apoptosis. In contrast, activation of the unfolded protein response should be inhibited for DCs to express immuno-modulatory molecules and cytokines. Here, we review recent advances on antigen CP, focusing on intracellular transport routes for exogenous antigens and distinctive subcellular compartments involved in ERAD. View Full-Text
Keywords: dendritic cells; cross-presentation; major histocompatibility class I; endoplasmic reticulum-associated degradation; unfolded protein response; inflammation dendritic cells; cross-presentation; major histocompatibility class I; endoplasmic reticulum-associated degradation; unfolded protein response; inflammation
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Imai, J.; Otani, M.; Sakai, T. Distinct Subcellular Compartments of Dendritic Cells Used for Cross-Presentation. Int. J. Mol. Sci. 2019, 20, 5606.

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