Special Issue "Therapeutic Strategies to Spinal Cord Injury"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (20 April 2018)
A printed edition of this Special Issue is available here.
Assoc. Prof. Pavla Jendelova
Institute of Experimental Medicine, Academy of Sciences of the Czech, Republic, Vídeňská 1083, Prague 142 20, Czech Republic
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Interests: spinal cord injury; neuroregeneration; axonal growth; cell therapy; inhibitory molecules; growth factors; astrogliosis; remyelination; neuroinflammation; biomaterials
Traumatic spinal cord injury (SCI) results in an immediate loss of motor and sensory function below the injury site and is associated with a poor prognosis. The inhibitory environment that develops in response to the injury is mainly due to local expression of inhibitory factors, scarring and the formation of cystic cavitations, all of which limit the regenerative capacity of endogenous cells. Current treatment modalities are focused on minimizing secondary injury and maximizing residual function via rehabilitation. Strategies that demonstrate promising results are performed in areas such as cellular therapy, growth factors (BDNF), inhibitory molecules, fibroglial scar, gene therapies, etc. Other promising experimental treatments focus on neuroprotection with hypothermia and pharmacologic therapies, regeneration facilitation via biomaterial transplantation, and rewiring with electrical stimulation. Some strategies have provided encouraging results by themselves; others have been tested as a combination, showing an improved outcome after SCI. Experimental evidence suggests that it is possible to obtain better results with a combination of strategies, which justifies further research for therapeutic approaches. This Special Issue intends to provide the most relevant information about available up-to-date therapeutic strategies that are administered alone or in combination with others, and have offered the best results in neural regeneration after spinal cord injury.
Assoc. Prof. Pavla Jendelova
Manuscript Submission Information
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- spinal cord injury
- axonal growth
- cell therapy
- inhibitory molecules
- growth factors