Int. J. Mol. Sci. 2018, 19(4), 1039; https://doi.org/10.3390/ijms19041039
Stem Cells Therapy for Spinal Cord Injury
Marina Gazdic 1
, Vladislav Volarevic 2, C. Randall Harrell 3, Crissy Fellabaum 3, Nemanja Jovicic 4, Nebojsa Arsenijevic 2 and Miodrag Stojkovic 1,5,*
, Vladislav Volarevic 2, C. Randall Harrell 3, Crissy Fellabaum 3, Nemanja Jovicic 4, Nebojsa Arsenijevic 2 and Miodrag Stojkovic 1,5,*
1
Faculty of Medical Sciences, Department of Genetics, University of Kragujevac, 34000 Kragujevac, Serbia
2
Faculty of Medical Sciences, Department of Microbiology and immunology, Center for Molecular Medicine and Stem Cell Research, University of Kragujevac, 34000 Kragujevac, Serbia
3
Regenerative Processing Plant, LLC, 34176 US Highway 19 N Palm Harbor, Palm Harbor, FL 34684, USA
4
Faculty of Medical Sciences, Department of Histology and embryology, University of Kragujevac, 34000 Kragujevac, Serbia
5
Spebo Medical, 16 Norvezanska, 16000 Leskovac, Serbia
*
Author to whom correspondence should be addressed.
Received: 10 February 2018 / Revised: 26 February 2018 / Accepted: 5 March 2018 / Published: 30 March 2018
(This article belongs to the Special Issue Therapeutic Strategies to Spinal Cord Injury)
Abstract
Spinal cord injury (SCI), a serious public health issue, most likely occurs in previously healthy young adults. Current therapeutic strategies for SCI includes surgical decompression and pharmacotherapy, however, there is still no gold standard for the treatment of this devastating condition. Inefficiency and adverse effects of standard therapy indicate that novel therapeutic strategies are required. Because of their neuroregenerative and neuroprotective properties, stem cells are a promising tool for the treatment of SCI. Herein, we summarize and discuss the promising therapeutic potential of human embryonic stem cells (hESC), induced pluripotent stem cells (iPSC) and ependymal stem/progenitor cells (epSPC) for SCI. View Full-TextKeywords:
spinal cord injury; stem cells; embryonic stem cells; induced pluripotent stem cells; ependymal stem/progenitor cells
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Gazdic, M.; Volarevic, V.; Harrell, C.R.; Fellabaum, C.; Jovicic, N.; Arsenijevic, N.; Stojkovic, M. Stem Cells Therapy for Spinal Cord Injury. Int. J. Mol. Sci. 2018, 19, 1039.
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