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The Role of the Circadian Clock in Cancer and Inflammatory Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (15 March 2023) | Viewed by 7185

Special Issue Editor

Dr. Eva Maria Sturm

E-Mail Website
Guest Editor
Otto Loewi Research Center for Vascular Biology, Immunology and Inflammation, Division of Pharmacology, Medical University of Graz, 8010 Graz, Austria
Interests: immunology; inflammatory diseases; allergy; eosinophils; signaling; cytokines; eicosanoids

Special Issue Information

Dear Colleagues,

The circadian clock is a crucial regulator of daily physiological processes and also orchestrates the function of our immune system, both, at steady-state and under inflammatory conditions. On the cellular level, the molecular circadian clock coordinates transcriptional-translational feedback loops driven by the transcription factor heterodimer BMAL1/CLOCK that activates oscillating expression patterns of many genes involved in cellular functions. Accordingly, several diseases display a marked time-of-day pattern in symptoms. Recent studies have linked disruption and disturbances of circadian rhythms to increased susceptibility of chronic inflammatory diseases and cancer development. Moreover, loss of circadian homeostasis also influences responses to many types of treatment.

This Special Issue covers the role of the circadian clock in the development of several types of cancer and chronic inflammatory diseases, the interaction of the immune system with the circadian clock under homeostatic and diseased conditions, the impact of the circadian clock on treatment outcome, recent advances in chronotherapeutic approaches and the therapeutic value of small-molecule modulators of the circadian clock for cancer and chronic inflammation.

Dr. Eva Maria Sturm
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer
  • chronic inflammatory disease
  • gene expression
  • circadian clock in pathology
  • circadian clock under steady-state
  • chronotherapy
  • small-molecule modulators of the circadian clock
  • regulation of the circadian clock
  • circadian clock-immune system interaction

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Published Papers (2 papers)

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Research

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10 pages, 1088 KiB  
Communication
Association of Circadian Clock Gene Expression with Pediatric/Adolescent Asthma and Its Comorbidities
by Nguyen Quoc Vuong Tran, Minh-Khang Le, Thuy-An Nguyen, Tetsuo Kondo and Atsuhito Nakao
Int. J. Mol. Sci. 2023, 24(8), 7477; https://doi.org/10.3390/ijms24087477 - 19 Apr 2023
Cited by 1 | Viewed by 1528
Abstract
The pathology of asthma is characterized by marked day–night variation, which is likely controlled by circadian clock activity. This study aimed to clarify the association of core circadian clock gene expression with clinical features of asthma. For this purpose, we accessed the National [...] Read more.
The pathology of asthma is characterized by marked day–night variation, which is likely controlled by circadian clock activity. This study aimed to clarify the association of core circadian clock gene expression with clinical features of asthma. For this purpose, we accessed the National Center for Biotechnology Information database and analyzed transcriptomes of peripheral blood mononuclear cells and clinical characteristics of 134 pediatric/adolescent patients with asthma. Based on the expression patterns of seven core circadian clock genes (CLOCK, BMAL1, PER1-3, CRY1-2), we identified three circadian clusters (CCs) with distinct comorbidities and transcriptomic expressions. In the three CC subtypes, allergic rhinitis, and atopic dermatitis, both asthma comorbidities occurred in different proportions: CC1 had a high proportion of allergic rhinitis and atopic dermatitis; CC2 had a high proportion of atopic dermatitis but a low proportion of allergic rhinitis; and CC3 had a high proportion of allergic rhinitis but a low proportion of atopic dermatitis. This might be associated with the low activity of the FcεRI signaling pathway in CC2 and the cytokine–cytokine receptor interaction pathways in CC3. This is the first report to consider circadian clock gene expression in subcategories of patients with asthma and to explore their contribution to pathophysiology and comorbidity. Full article
(This article belongs to the Special Issue The Role of the Circadian Clock in Cancer and Inflammatory Diseases)
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Review

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15 pages, 1287 KiB  
Review
Role of Melatonin in Cancer: Effect on Clock Genes
by César Rodríguez-Santana, Javier Florido, Laura Martínez-Ruiz, Alba López-Rodríguez, Darío Acuña-Castroviejo and Germaine Escames
Int. J. Mol. Sci. 2023, 24(3), 1919; https://doi.org/10.3390/ijms24031919 - 18 Jan 2023
Cited by 13 | Viewed by 5113
Abstract
The circadian clock is a regulatory system, with a periodicity of approximately 24 h, that generates rhythmic changes in many physiological processes. Increasing evidence links chronodisruption with aberrant functionality in clock gene expression, resulting in multiple diseases, including cancer. In this context, tumor [...] Read more.
The circadian clock is a regulatory system, with a periodicity of approximately 24 h, that generates rhythmic changes in many physiological processes. Increasing evidence links chronodisruption with aberrant functionality in clock gene expression, resulting in multiple diseases, including cancer. In this context, tumor cells have an altered circadian machinery compared to normal cells, which deregulates the cell cycle, repair mechanisms, energy metabolism and other processes. Melatonin is the main hormone produced by the pineal gland, whose production and secretion oscillates in accordance with the light:dark cycle. In addition, melatonin regulates the expression of clock genes, including those in cancer cells, which could play a key role in the numerous oncostatic effects of this hormone. This review aims to describe and clarify the role of clock genes in cancer, as well as the possible mechanisms of the action of melatonin through which it regulates the expression of the tumor’s circadian machinery, in order to propose future anti-neoplastic clinical treatments. Full article
(This article belongs to the Special Issue The Role of the Circadian Clock in Cancer and Inflammatory Diseases)
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