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Special Issue "Cell Adhesion and Migration in Health and Diseases"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 15 March 2020.

Special Issue Editor

Guest Editor
Prof. Motomu Shimaoka Website E-Mail
Mie University School of Medicine, Tsu, Japan

Special Issue Information

Dear Colleagues,

This Special Issue focuses on the biology and pathobiology of cell adhesion and migration. Cell adhesion and migration represent a biological phenomenon that plays many important roles in health and diseases: from organ development, host defense, hemostasis, to cancer, inflammation, and thrombosis. The topics covered include but are not limited to: intracellular and extracellular signaling mechanisms regulating cell adhesion and migration; adhesive interactions involved in homeostasis and disease pathogenesis; genetics and gene regulation in cell adhesion; cytokines and chemokines affecting cell adhesive interactions; cell migration in diseases and animal models; experimental therapeutics to interfere with cell adhesion; and biophysics and bioengineering of cell adhesion. Original investigations as well as concise review manuscripts from experts in the relevant research fields will be considered for publication.

Prof. Motomu Shimaoka
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Cell adhesion molecules
  • Cell migration
  • Trafficking
  • Homing
  • Metastasis
  • Invasion
  • Integrins
  • Selectins
  • Cadherin
  • Chemokines
  • Cytokines
  • Leukocyte
  • Endothelial cell
  • Cancer
  • Mesenchymal cell
  • Extracellular matrix
  • Cytoskeleton
  • Glycocalyx
  • Mechanotransduction
  • Antibody
  • Antagonist/inhibitor
  • Inflammation
  • Immunology
  • Adherent junction

Published Papers (1 paper)

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Research

Open AccessArticle
Use Microfluidic Chips to Study the Phototaxis of Lung Cancer Cells
Int. J. Mol. Sci. 2019, 20(18), 4515; https://doi.org/10.3390/ijms20184515 - 12 Sep 2019
Abstract
Cell migration is an important process involved in wound healing, tissue development, and so on. Many studies have been conducted to explore how certain chemicals and electric fields induce cell movements in specific directions, which are phenomena termed chemotaxis and electrotaxis, respectively. However, [...] Read more.
Cell migration is an important process involved in wound healing, tissue development, and so on. Many studies have been conducted to explore how certain chemicals and electric fields induce cell movements in specific directions, which are phenomena termed chemotaxis and electrotaxis, respectively. However, phototaxis, the directional migration of cells or organisms toward or away from light, is rarely investigated due to the difficulty of generating a precise and controllable light gradient. In this study, we designed and fabricated a microfluidic chip for simultaneously culturing cells and generating a blue light gradient for guiding cell migration. A concentration gradient was first established inside this chip, and by illuminating it with a blue light-emitting diode (LED), a blue light gradient was generated underneath. Cell migration in response to this light stimulus was observed. It was found that lung cancer cells migrated to the dark side of the gradient, and the intracellular reactive oxygen species (ROS) was proportional to the intensity of the blue light. Full article
(This article belongs to the Special Issue Cell Adhesion and Migration in Health and Diseases)
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