Next Article in Journal
Neuroprotective Role of Dietary Supplementation with Omega-3 Fatty Acids in the Presence of Basal Forebrain Cholinergic Neurons Degeneration in Aged Mice
Next Article in Special Issue
Long-Tailed Unconventional Class I Myosins in Health and Disease
Previous Article in Journal
Correction: Cherkaoui, M., Lollier, V., Geairon, A., Bouder, A., Larré, C., Rogniaux, H., Jamet, E., Guillon, F. and Francin-Allami, M. Cell Wall Proteome of Wheat Grain Endosperm and Outer Layers at Two Key Stages of Early Development. Int. J. Mol. Sci. 2020, 21, 239
Previous Article in Special Issue
Junctional Adhesion Molecule-C Mediates the Recruitment of Embryonic-Endothelial Progenitor Cells to the Perivascular Niche during Tumor Angiogenesis
Review

Transient Receptor Potential Canonical (TRPC) Channels as Modulators of Migration and Invasion

1
Minerva Foundation Institute for Medical Research, Biomedicum Helsinki 2U, Tukholmankatu 8, 00290 Helsinki, Finland
2
Faculty of Science and Engineering, Cell Biology, Åbo Akademi University, Tykistökatu 6A, 20520 Turku, Finland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(5), 1739; https://doi.org/10.3390/ijms21051739
Received: 11 February 2020 / Revised: 25 February 2020 / Accepted: 26 February 2020 / Published: 3 March 2020
(This article belongs to the Special Issue Cell Adhesion and Migration in Health and Diseases)
Calcium (Ca2+) is perhaps the most versatile signaling molecule in cells. Ca2+ regulates a large number of key events in cells, ranging from gene transcription, motility, and contraction, to energy production and channel gating. To accomplish all these different functions, a multitude of channels, pumps, and transporters are necessary. A group of channels participating in these processes is the transient receptor potential (TRP) family of cation channels. These channels are divided into 29 subfamilies, and are differentially expressed in man, rodents, worms, and flies. One of these subfamilies is the transient receptor potential canonical (TRPC) family of channels. This ion channel family comprises of seven isoforms, labeled TRPC1–7. In man, six functional forms are expressed (TRPC1, TRPC3–7), whereas TRPC2 is a pseudogene; thus, not functionally expressed. In this review, we will describe the importance of the TRPC channels and their interacting molecular partners in the etiology of cancer, particularly in regard to regulating migration and invasion. View Full-Text
Keywords: TRPC; ion channels; cancer; thyroid; calcium; migration; invasion; angiogenesis TRPC; ion channels; cancer; thyroid; calcium; migration; invasion; angiogenesis
Show Figures

Figure 1

MDPI and ACS Style

Asghar, M.Y.; Törnquist, K. Transient Receptor Potential Canonical (TRPC) Channels as Modulators of Migration and Invasion. Int. J. Mol. Sci. 2020, 21, 1739. https://doi.org/10.3390/ijms21051739

AMA Style

Asghar MY, Törnquist K. Transient Receptor Potential Canonical (TRPC) Channels as Modulators of Migration and Invasion. International Journal of Molecular Sciences. 2020; 21(5):1739. https://doi.org/10.3390/ijms21051739

Chicago/Turabian Style

Asghar, Muhammad Y.; Törnquist, Kid. 2020. "Transient Receptor Potential Canonical (TRPC) Channels as Modulators of Migration and Invasion" Int. J. Mol. Sci. 21, no. 5: 1739. https://doi.org/10.3390/ijms21051739

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop