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Gastrointestinal Nematode-Derived Antigens Alter Colorectal Cancer Cell Proliferation and Migration through Regulation of Cell Cycle and Epithelial-Mesenchymal Transition Proteins

1
Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town 7925, South Africa
2
Department of Human Biology, University of Cape Town, Cape Town 7925, South Africa
3
School of Medicine, Cardiff University, Cardiff CF14 3XN, UK
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(21), 7845; https://doi.org/10.3390/ijms21217845
Received: 3 September 2020 / Revised: 15 October 2020 / Accepted: 19 October 2020 / Published: 22 October 2020
(This article belongs to the Special Issue Cell Adhesion and Migration in Health and Diseases)
As the global incidences of colorectal cancer rises, there is a growing importance in understanding the interaction between external factors, such as common infections, on the initiation and progression of this disease. While certain helminth infections have been shown to alter the severity and risk of developing colitis-associated colorectal cancer, whether these parasites can directly affect colorectal cancer progression is unknown. Here, we made use of murine and human colorectal cancer cell lines to demonstrate that exposure to antigens derived from the gastrointestinal nematode Heligmosomoides polygyrus significantly reduced colorectal cancer cell proliferation in vitro. Using a range of approaches, we demonstrate that antigen-dependent reductions in cancer cell proliferation and viability are associated with increased expression of the critical cell cycle regulators p53 and p21. Interestingly, H. polygyrus-derived antigens significantly increased murine colorectal cancer cell migration, which was associated with an increased expression of the adherens junction protein β-catenin, whereas the opposite was true for human colorectal cancer cells. Together, these findings demonstrate that antigens derived from a gastrointestinal nematode can significantly alter colorectal cancer cell behavior. Further in-depth analysis may reveal novel candidates for targeting and treating late-stage cancer. View Full-Text
Keywords: colorectal cancer; gastrointestinal nematode; proliferation; migration colorectal cancer; gastrointestinal nematode; proliferation; migration
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MDPI and ACS Style

Jacobs, B.-A.; Prince, S.; Smith, K.A. Gastrointestinal Nematode-Derived Antigens Alter Colorectal Cancer Cell Proliferation and Migration through Regulation of Cell Cycle and Epithelial-Mesenchymal Transition Proteins. Int. J. Mol. Sci. 2020, 21, 7845. https://doi.org/10.3390/ijms21217845

AMA Style

Jacobs B-A, Prince S, Smith KA. Gastrointestinal Nematode-Derived Antigens Alter Colorectal Cancer Cell Proliferation and Migration through Regulation of Cell Cycle and Epithelial-Mesenchymal Transition Proteins. International Journal of Molecular Sciences. 2020; 21(21):7845. https://doi.org/10.3390/ijms21217845

Chicago/Turabian Style

Jacobs, Brittany-Amber; Prince, Sharon; Smith, Katherine A. 2020. "Gastrointestinal Nematode-Derived Antigens Alter Colorectal Cancer Cell Proliferation and Migration through Regulation of Cell Cycle and Epithelial-Mesenchymal Transition Proteins" Int. J. Mol. Sci. 21, no. 21: 7845. https://doi.org/10.3390/ijms21217845

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