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Molecular Mechanisms of C-Reactive Protein
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Molecular Mechanisms of C-Reactive Protein

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (20 January 2025) | Viewed by 2790

Special Issue Editor

Prof. Dr. Mark Slevin

E-Mail Website
Guest Editor
1. Centre for Advanced Medical and Pharmaceutical Research, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, 540142 Târgu Mureș, Romania
2. The School of Life Sciences, Manchester Metropolitan University, Manchester M1 5QA, UK
Interests: C-Reactive protein; stem cell; drug delivery; neurodegenerative disease; stroke; autoimmune disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The aim of this series is to provide an understanding of the complex cell and molecular mechanisms through which monomeric C-reactive protein (mCRP) induces responses in host tissues and cells, driving various pathological conditions. In this group of publications, the receptor-mediated activation of signaling pathways linked to inflammation, angiogenesis, and other aberrant responses will be evaluated. The link between mCRP and the development as well as progression of both acute and chronic diseases, such as atherosclerosis, Alzheimer’s disease, diabetes, and diabetic complications, can be considered within this series.

This Special Issue of the International Journal of Molecular Sciences on “Molecular Mechanisms of C-Reactive Protein”, supervised by Prof. Dr. Mark Slevin (Manchester Metropolitan University; George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures) and assisted by Dr. Ylenia Pastorello (George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures), aims at providing cutting-edge knowledge on every aspect of C-reactive protein.

Prof. Dr. Mark Slevin
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • C-reactive protein
  • cell signalling
  • inflammation
  • pathological processes

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Published Papers (2 papers)

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Research

10 pages, 2655 KiB  
Article
Changes in the Level of hs-CRP in the Blood and Morphometric Parameters of Tissues Following Implantation of Polypropylene
by Igor A. Eisenach, Galina A. Lapii, Alexandra K. Uzyumova, Elena L. Lushnikova, Victor S. Ovchinnikov, Anastasia O. Solovieva, Orlan V. Oorzhak and Alexey V. Kuznetsov
Int. J. Mol. Sci. 2025, 26(4), 1419; https://doi.org/10.3390/ijms26041419 - 7 Feb 2025
Viewed by 486
Abstract
In recent decades, the use of polypropylene meshes has been the gold standard in the surgical treatment of muscular corset failure. However, the reasons behind the low percentage of complications and recurrences remain controversial. Tissue hyperreactivity and the immune response to polypropylene may [...] Read more.
In recent decades, the use of polypropylene meshes has been the gold standard in the surgical treatment of muscular corset failure. However, the reasons behind the low percentage of complications and recurrences remain controversial. Tissue hyperreactivity and the immune response to polypropylene may be contributing factors. Measurements of the level of hs-CRP (highly sensitive C-reactive protein) in the blood and morphometric studies of tissues around the implant were carried out for three months after the installation of polypropylene implants in 53 laboratory rats. The research results confirmed the good biocompatibility of polypropylene and the formation of full-fledged connective tissue around polypropylene three months after the installation of the material. The level of hs-CRP in the blood increased slightly, without significant differences, but in some animals, there was a sharp increase in this indicator at 3 months. Such results may indicate the development of hyperreactivity to the implantation of a synthetic material and, with other accompanying factors, lead to the development of complications both at the local tissue and general immune levels. Full article
(This article belongs to the Special Issue Molecular Mechanisms of C-Reactive Protein)
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14 pages, 3305 KiB  
Article
mCRP-Induced Focal Adhesion Kinase-Dependent Monocyte Aggregation and M1 Polarization, Which Was Partially Blocked by the C10M Inhibitor
by Ylenia Pastorello, Doina Manu, Xenia Sawkulycz, Vittorio Caprio, Claudia Banescu, Minodora Dobreanu, Lawrence Potempa, Mario Di Napoli and Mark Slevin
Int. J. Mol. Sci. 2024, 25(6), 3097; https://doi.org/10.3390/ijms25063097 - 7 Mar 2024
Cited by 3 | Viewed by 1566
Abstract
Monomeric C-reactive protein (mCRP) has recently been implicated in the abnormal vascular activation associated with development of atherosclerosis, but it may act more specifically through mechanisms perpetuating damaged vessel inflammation and subsequent aggregation and internalization of resident macrophages. Whilst the direct effects of [...] Read more.
Monomeric C-reactive protein (mCRP) has recently been implicated in the abnormal vascular activation associated with development of atherosclerosis, but it may act more specifically through mechanisms perpetuating damaged vessel inflammation and subsequent aggregation and internalization of resident macrophages. Whilst the direct effects of mCRP on endothelial cells have been characterized, the interaction with blood monocytes has, to our knowledge, not been fully defined. Here we showed that mCRP caused a strong aggregation of both U937 cell line and primary peripheral blood monocytes (PBMs) obtained from healthy donors. Moreover, this increase in clustering was dependent on focal adhesion kinase (FAK) activation (blocked by a specific inhibitor), as was the concomitant adhesive attachment to the plate, which was suggestive of macrophage differentiation. Confocal microscopy confirmed the increased expression and nuclear localization of p-FAK, and cell surface marker expression associated with M1 macrophage polarization (CD11b, CD14, and CD80, as well as iNOS) in the presence of mCRP. Inclusion of a specific CRP dissociation/mCRP inhibitor (C10M) effectively inhibited PBMs clustering, as well as abrogating p-FAK expression, and partially reduced the expression of markers associated with M1 macrophage differentiation. mCRP also increased the secretion of pro-inflammatory cytokines Interleukin-8 (IL-8) and Interleukin-1β (IL-1β), without notably affecting MAP kinase signaling pathways; inclusion of C10M did not perturb or modify these effects. In conclusion, mCRP modulates PBMs through a mechanism that involves FAK and results in cell clustering and adhesion concomitant with changes consistent with M1 phenotypical polarization. C10M has potential therapeutic utility in blocking the primary interaction of mCRP with the cells—for example, by protecting against monocyte accumulation and residence at damaged vessels that may be predisposed to plaque development and atherosclerosis. Full article
(This article belongs to the Special Issue Molecular Mechanisms of C-Reactive Protein)
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