Special Issue "Cellular and Molecular Mechanisms of Blood–Brain Barrier Dysfunction"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 March 2020).
Interests: vascular dementia; Alzheimer’s disease; neuroinflammation; neuropathology
Interests: Alzheimer’s disease; astrocytes; insulin/IGF1 signalling
The blood–brain barrier comprises a highly specialised complex of cells within the neurovascular unit, and is responsible for tightly regulating homeostasis within the central nervous system, which is critical to maintain neuronal function. Dysfunction of the blood–brain barrier is a key pathological feature of a range of neurodegenerative diseases including Alzheimer’s Disease, cerebrovascular disorders including stroke and vascular dementia, and neuroinflammatory diseases including multiple sclerosis. Loss of blood–brain barrier integrity can result in pathological permeability resulting in the entry of immune cells and/or molecules into the central nervous system which stimulate a neuroinflammatory response, as well as ion dysregulation and altered signalling homeostasis, processes that contribute to neuronal dysfunction and neurodegeneration. Deciphering the mechanisms underlying dysfunction of the blood-brain barrier is an important area to identify and develop potential disease-modifying treatments.
This Special Issue of IJMS provides a comprehensive synopsis of current blood–brain barrier research from cellular to molecular mechanisms, the relationship between blood–brain barrier dysfunction and the neuroinflammatory response, and animal/cell models to study the molecular mechanisms underlying the pathophysiology of blood–brain barrier disruption.
You are warmly invited to submit original research and review articles related to any of these aspects.
Prof. Dr. Julie E. Simpson
Dr. Claire J. Garwood
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Alzheimer’s disease
- Blood–brain barrier
- Endothelial dysfunction
- Multiple sclerosis
- Tight junction proteins
- Vascular dementia