Molecular Biology of Age-Related Macular Degeneration (AMD) 2.0
This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Special Issue Information
Dear Colleagues,
Age-related macular degeneration (AMD) is the main cause of blindness in the elderly in developed countries and is an emerging health and social problem, as the number of individuals affected by AMD in 2020 is estimated to reach about 200 million. Therefore, AMD is an important element of the global issue of vision loss. Additionally, there is no efficient treatment in most AMD cases. AMD is a complex disease that is associated with aging and several genetic and environmental risk factors. Cellular reaction to oxidative stress, senescence, autophagy, inflammatory response, and DNA damage reaction are frequently reported to be impaired in AMD, but causative relationships between AMD and these effects are not completely clear. Therefore, studies on the molecular mechanisms of AMD pathogenesis are justified and can bring results important regarding its biology and therapy.
This Special Issue welcomes both original papers and review articles addressing one or several of the abovementioned issues, or of the topics mentioned in the keywords listed below.
This Special Issue is the continuation of our previous Special Issue, “Molecular Biology of Age-Related Macular Degeneration (AMD)”.
Prof. Dr. Janusz Blasiak
Prof. Dr. Kai Kaarniranta
Guest Editors
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Keywords
- AMD pathogenesis
- Retinal pigment epithelium, photoreceptors, and choriocapillaris in AMD
- Oxidative stress and antioxidant system in AMD
- Senescence and organismal aging in AMD
- Mitochondrial quality control in AMD
- Autophagy and mitophagy in AMD
- DNA damage reaction in the nucleus and mitochondria in retinal pigment epithelium
- DNA damage and repair in AMD
- AMD genetics: mutations and polymorphisms of genes related to AMD
- AMD epigenetics
- Programmed cell death, including apoptosis, pyroptosis, and necroptosis in ertinal pigment epithelium
- Inflammation and the inflammasome activation
- miRNA-lncRNA regulation in AMD
- Neurodegenerative diseases related to AMD
- Models to study AMD pathogenesis
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Published Papers
Int. J. Mol. Sci. - ISSN 1422-0067