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EMT and EndMT: Emerging Roles in Age-Related Macular Degeneration
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Experimental Models in Neovascular Age Related Macular Degeneration

Institute for Research on Cancer and Aging of Nice, CNRS UMR 7284, INSERM U1081, Centre Antoine Lacassagne, University Cote d’Azur (UCA), 06000 Nice, France
Biomedical Department, Centre Scientifique de Monaco, 98000 Monaco, Monaco
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(13), 4627;
Received: 9 June 2020 / Revised: 25 June 2020 / Accepted: 25 June 2020 / Published: 29 June 2020
(This article belongs to the Special Issue Molecular Biology of Age-Related Macular Degeneration (AMD) 2.0)
Neovascular age-related macular degeneration (vAMD), characterized by the neo-vascularization of the retro-foveolar choroid, leads to blindness within few years. This disease depends on angiogenesis mediated by the vascular endothelial growth factor A (VEGF) and to inflammation. The only available treatments consist of monthly intravitreal injections of antibodies directed against VEGF or VEGF/VEGFB/PlGF decoy receptors. Despite their relative efficacy, these drugs only delay progression to blindness and 30% of the patients are insensitive to these treatments. Hence, new therapeutic strategies are urgently needed. Experimental models of vAMD are essential to screen different innovative therapeutics. The currently used in vitro and in vivo models in ophthalmic translational research and their relevance are discussed in this review. View Full-Text
Keywords: neovascular age related macular degeneration (vAMD); wet AMD; in vitro model of AMD; mice and zebrafish model of AMD neovascular age related macular degeneration (vAMD); wet AMD; in vitro model of AMD; mice and zebrafish model of AMD
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Rastoin, O.; Pagès, G.; Dufies, M. Experimental Models in Neovascular Age Related Macular Degeneration. Int. J. Mol. Sci. 2020, 21, 4627.

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