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Endometriosis: From Molecular Basis to Therapy, 2nd Edition
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Endometriosis: From Molecular Basis to Therapy, 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 June 2025 | Viewed by 557

Special Issue Editor

Prof. Dr. Grzegorz Polak

E-Mail Website
Guest Editor
Department of Gynaecologic Oncology and Gynaecology, Medical University of Lublin, Staszica 16, 20-081 Lublin, Poland
Interests: endometriosis; ovarian; gynecology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Endometriosis is a polymorphous and subtle pathology that affects 1 in 10 women worldwide. Endometriosis-related pain severely affects people’s quality of life by impairing working efficiency, social life, and sexual function, among others. According to the lesion type and location, endometriosis is subdivided into peritoneal endometriosis, deep endometriosis, and endometrioma. Although research has improved our knowledge of the genetic and molecular pathways involved in endometriosis establishment and progression, this condition’s pathogenesis remains yet to be fully understood.

This Specia Issue of IJMS, led by Prof. Dr. Grzegorz Polak, aims to highlight recent insights and discoveries, novel developments, current challenges, and future perspectives in this field. We cordially invite paper submissions addressing any and all relevant aspects of this condition’s pathology.

Prof. Dr. Grzegorz Polak
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • endometriosis
  • endometriosis diagnosis
  • infertility
  • novel strategies

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Published Papers (1 paper)

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Research

23 pages, 2083 KiB  
Article
Pelvic Pain Symptoms and Inflammation Among Adolescents and Adults with and Without Endometriosis
by Amy L. Shafrir, Ashley Laliberte, Britani Wallace, Allison F. Vitonis, Christine B. Sieberg, Marzieh Ghiasi, Larry I. Magpantay, Marta Epeldegui, Andrew Schrepf, Sawsan As-Sanie, Kathryn L. Terry and Stacey A. Missmer
Int. J. Mol. Sci. 2025, 26(11), 5377; https://doi.org/10.3390/ijms26115377 - 4 Jun 2025
Viewed by 327
Abstract
We evaluated inflammatory markers among 389 surgically confirmed endometriosis cases and 505 controls from the Women’s Health Study: From Adolescence to Adulthood (A2A) cohort. Participants reported dysmenorrhea, acyclic pelvic pain, dyspareunia, and pain with bowel movements. Using multiplex assays, we measured their levels [...] Read more.
We evaluated inflammatory markers among 389 surgically confirmed endometriosis cases and 505 controls from the Women’s Health Study: From Adolescence to Adulthood (A2A) cohort. Participants reported dysmenorrhea, acyclic pelvic pain, dyspareunia, and pain with bowel movements. Using multiplex assays, we measured their levels of plasma interleukin (IL)-1β, -6, -8, -10, and -16, tumor necrosis factor (TNF)-α, monocyte chemotactic protein (MCP)-1 and -4, thymus and activation-regulated chemokine (TARC), and interferon gamma-induced protein (IP)-10. For each symptom, we computed biomarker-level geometric means (GMs) with 95% confidence intervals (95% CI) using multivariate linear regression among the endometriosis cases and controls, with interactions with case/control status tested using Wald statistics. Among the controls, those with dyspareunia had lower levels of IL-8 (GMpresent = 4.64 [95% CI = 4.41–4.89] pg/mL vs. GMabsent = 4.99 [95% CI = 4.82–5.17] pg/mL; p = 0.02), and the IL-8 levels were lower for controls reporting pain with bowel movements (GMpresent = 4.66 [95% CI = 4.43–4.89] vs. GMabsent = 4.96 [95% CI = 4.82–5.11] pg/mL, p = 0.03). No significant associations between pelvic pain symptoms and inflammatory markers were observed among the endometriosis cases; however, the relationship between inflammatory marker levels and pain experience varied by analgesic use at blood draw. Dyspareunia and pain with bowel movements were associated with inflammatory markers among the controls, while the associations between pelvic pain symptoms and inflammatory markers among the endometriosis cases differed by analgesic use. Full article
(This article belongs to the Special Issue Endometriosis: From Molecular Basis to Therapy, 2nd Edition)
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