Special Issue "Epigenetic Regulation in Human Disease"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 31 October 2023 | Viewed by 520
Special Issue Editor
Interests: clinical epigenetics (diagnostic and prognostic epi-signatures); EWAS; epigenetic editing (dCAS); epigenetics and machine learning; single-cell analyses
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Epigenetics comprises crucial mechanisms governing chromatin architecture and genome stability. In addition, these epigenetic mechanisms, in turn, regulate the expression of genes in different settings, such as in early development and cell differentiation, in response to environmental (external) factors or in response to/interaction with genetic (internal) variation. The epigenome is thus a highly dynamic regulatory system, and over the last decade the scientific interest in this field has increased tremendously. DNA methylation and histone modifications are, to date, the most commonly studied epigenetic features. Epigenetic regulation is controlled by a complex system of proteins involving epigenetic writers, readers, remodelers, and erasers. Genetic variation in genes encoding for such proteins often leads to severe diseases or syndromes. In many cases, specific epigenetic signatures are associated with particularly rare Mendelian disorders. Since the epigenome can be affected by external and environmental factors, it may also be associated with other classes of disease, including neuro-degenerative diseases, autoimmune diseases, cancer, and non-communicable as well as multi-factorial diseases. Recent progress in statistical methodologies, e.g., machine learning, network analysis, (integrative) multi-omics analyses, and other translational research (e.g., dCAS-based epigenetic editing), has paved the way towards a deeper understanding of the regulatory role of epigenetics within the pathophysiology of disease. In this Special Issue we invite you to submit an original research report or review article deciphering the role of the regulatory mechanism(s) of epigenetics in relation to disease and malignancies, (early) development, aging, or differentiation.
Dr. Peter Henneman
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- epigenetics
- integrative analysis
- regulatory mechanism
- multi-omics
- chromatin
