Advances in DNA Methylation
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biomacromolecules: Nucleic Acids".
Deadline for manuscript submissions: closed (15 June 2023) | Viewed by 13076
Special Issue Editor
Interests: clinical epigenetics (diagnostic and prognostic epi-signatures); EWAS; epigenetic editing (dCAS); epigenetics and machine learning; single-cell analyses
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
DNA methylation (DNAm) and histone modifications (HMs) are crucial mechanisms governing chromatin architecture and genome stability and are the most commonly studied epigenetic features. The epigenome represents a highly dynamic mechanism controlled by a complex system of proteins involving epigenetic writers, readers, remodelers, and erasers. Genetic variation in genes encoding for such proteins often leads to severe disease or syndromes. On the other hand, it can also be affected by external and environmental factors, which may also lead to or be associated with disease. Epigenetic changes can contribute to the development of numerous diseases, including neurodegenerative, autoimmune diseases, cancer, and noncommunicable and multifactorial diseases. Recent progress in statistical methodology and approaches is paving the way toward deeper insight into the role of epigenetics and related molecular mechanisms within the pathophysiology of disease. Machine learning, network analysis, and multiomics analyses are to date frequently implemented in order to develop a whole new set of diagnostic and prognostic, and basal biology, toolkits. Moreover, since the epigenome is dynamic by definition, epigenetic editing, by means of (d)CAS fusion proteins or by small epigenetically active molecules, seems to be a promising future direction for intervention strategies.
In this Special Issue, we invite you to submit an original research report or review article deciphering the role of DNA methylation in malignancies, aging or differentiation.
Dr. Peter Henneman
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Keywords
- DNA methylation
- Epigenetics
- Signature
- epigenetic editing, machine learning.
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