Mitochondrial Metabolic Alterations in Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (29 November 2023) | Viewed by 5077
Special Issue Editors
Interests: mitochondrial transporters; bioenergetics; mitochondrial diseases; cancers metabolism
Special Issues, Collections and Topics in MDPI journals
Interests: bioenergetics; mitochondrial carriers; mutagenesis, drosophila melanogaster; mitochondrial diseases; mitochondrial dysfunction; apoptosis; ROS; antioxidant and anti-inflammatory activity; cancer metabolism; anticancer agents
Special Issues, Collections and Topics in MDPI journals
Interests: ketogenic diet; microRNAs signature; catalase; heavy metals metabolic effects; epigenetics; apoptosis; antioxidant effects
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Mitochondria are essential in ATP generation and cellular bioenergetic metabolism, and in the biosynthesis of macromolecules, ROS production, redox balance and apoptotic signaling, which are involved in carcinogenesis. Mitochondria play a critical role in cancer initiation, as mutations in mtDNA and nuclear-encoded mitochondrial genes alter cell metabolism, affect oxidative respiration and promote oxidative stress and epigenetic processes.
Furthermore, mitochondria are involved in cancer promotion and progression, as later stages of tumor progression are rather associated with mitochondrial metabolic reprogramming by oncogenes, mitochondrial dynamics and oxidative stress. In this view, mitochondria can act as “stress sensors” able to influence cancer cell metabolic adaptations to the microenvironment.
Mechanisms underlying cancer initiation, promotion and progression are multiple, complex and should be further investigated. On this basis, mitochondrial metabolism can represent an interesting potential target for cancer therapy.
This Special Issue will focus on investigating mechanisms by which alterations of mitochondrial metabolism can be implicated in cancer initiation, promotion and progression, in order to understand the molecular basis of cancer. We welcome the submission of original research manuscripts and reviews focusing on the implications of alterations in mitochondrial metabolism and dynamics in cancer, as well as those aimed at targeting mitochondrial metabolism as novel promising therapeutic strategies.
Prof. Dr. Vincenza Dolce
Dr. Rosita Curcio
Dr. Graziantonio Lauria
Guest Editors
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Keywords
- bioenergetics
- cancer metabolism
- ROS
- OXPHOS
- mitochondrial dysfunction in cancer
- mtDNA
- metabolic reprogramming
- cancer therapy
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