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Male Infertility: From Molecular Mechanisms to Therapeutic Strategies

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: closed (31 October 2024) | Viewed by 3517

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Guest Editor
Department of Animal Biotechnology, Kyungpook National University, Daegu 37224, Republic of Korea
Interests: reproduction; reproductive toxicology; endocrine disruptor; biomarker; fertility; infertility; spermatozoa; spermatogenesis; pesticide
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Special Issue Information

Dear Colleagues,

Male infertility is a complex condition affecting a significant proportion of the male population worldwide, contributing to nearly half of all infertility cases in couples. Understanding the intricate molecular mechanisms underlying male infertility is crucial for developing effective diagnostic and therapeutic strategies. This Special Issue aims to provide a comprehensive overview of the recent advancements in the molecular understanding of male infertility and highlight emerging therapeutic approaches.

This Special Issue covers the molecular mechanisms of male infertility (genetic factors, epigenetic modifications, oxidative stress, and endocrine disruptors), diagnostic advances (genomic and proteomic profiling, image techniques, and sperm analysis), and therapeutic strategies (gene therapy, antioxidant therapy, hormonal treatments, and assisted reproductive technologies).

Dr. Woo-Sung Kwon
Guest Editor

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Keywords

  • male fertility
  • male infertility
  • sperm
  • molecular mechanisms
  • sperm function

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Published Papers (2 papers)

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12 pages, 682 KiB  
Article
CAGn Polymorphic Locus of Androgen Receptor (AR) Gene in Russian Infertile and Fertile Men
by Vyacheslav Chernykh, Olga Solovova, Tatyana Sorokina, Maria Shtaut, Anna Sedova, Elena Bliznetz, Olga Ismagilova, Tatiana Beskorovainaya, Olga Shchagina and Aleksandr Polyakov
Int. J. Mol. Sci. 2024, 25(22), 12183; https://doi.org/10.3390/ijms252212183 - 13 Nov 2024
Viewed by 986
Abstract
The androgen receptor (AR) is critical for mediating the effects of androgens. The polymorphic CAGn locus in exon 1 of the AR gene is associated with several diseases, including spinal and bulbar muscular atrophy (SBMA), prostate cancer, and male infertility. This study [...] Read more.
The androgen receptor (AR) is critical for mediating the effects of androgens. The polymorphic CAGn locus in exon 1 of the AR gene is associated with several diseases, including spinal and bulbar muscular atrophy (SBMA), prostate cancer, and male infertility. This study evaluated the CAGn locus in 9000 infertile Russian men and 286 fertile men (control group). The CAGn locus was analyzed using the amplified fragment length polymorphism method. In the infertile cohort, the number of CAG repeats ranged from 6 to 46, with a unimodal distribution. The number of CAG repeats in infertile and fertile men was 22.15 ± 0.93 and 22.02 ± 1.36, respectively. In infertile men, variants with 16 to 29 repeats were present in 97% of the alleles. A complete mutation (≥42 CAG repeats) was found in three patients, while three others had 39-41 repeats. The incidence of SBMA was 1:3000 infertile men. Significant differences (p < 0.05) were observed between infertile and fertile men in alleles with 21, 24 and 25 repeats. This study revealed certain differences in the CAGn polymorphic locus of the AR gene in Russian infertile and fertile men and determined the frequency of SBMA in infertile patients. Full article
(This article belongs to the Special Issue Male Infertility: From Molecular Mechanisms to Therapeutic Strategies)
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12 pages, 1204 KiB  
Article
Sperm Migration and Hyaluronic Acid Binding: Implications for Male Fertility Evaluation
by Katarzyna Marchlewska, Marta Erkiert-Kusiak, Renata Walczak-Jędrzejowska and Jolanta Słowikowska-Hilczer
Int. J. Mol. Sci. 2024, 25(18), 9995; https://doi.org/10.3390/ijms25189995 - 17 Sep 2024
Cited by 1 | Viewed by 2202
Abstract
Mature, vital, and motile spermatozoa are essential for reaching the oocyte and binding to hyaluronic acid (HA) in the cumulus oophorus matrix. This study aims to determine the relationship between sperm-migration ability and HA-binding potential, as well as the relationship between sperm concentration [...] Read more.
Mature, vital, and motile spermatozoa are essential for reaching the oocyte and binding to hyaluronic acid (HA) in the cumulus oophorus matrix. This study aims to determine the relationship between sperm-migration ability and HA-binding potential, as well as the relationship between sperm concentration and motility. Semen samples were collected from 702 men aged 20–56 years (median 34.8). We evaluated the sperm concentration and motility from basic semen analysis, the swim-up test (expressed as millions per mL and the migration efficiency percentage), and the hyaluronan-binding assay (HBA). A moderate positive correlation was found between the migration test results and HBA (R = 0.48). The highest correlation was observed between the concentration of motile spermatozoa and the migration test results (R = 0.85) and HBA (R = 0.4). The sperm migration efficiency strongly correlated with progressive motility (R = 0.6). Although significantly higher sperm migration was observed in patients with normal HBA results, the results of the functional tests were found to differ in some cases. For infertility treatment, the current diagnostic algorithm should be enhanced with more comprehensive seminological methods that assess the sperm-migration ability and HA-binding potential. We also recommend incorporating the swim-up method into the diagnostic protocol before planning assisted reproductive technology (ART) treatment. Full article
(This article belongs to the Special Issue Male Infertility: From Molecular Mechanisms to Therapeutic Strategies)
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