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Molecular Mechanisms Underlying Sperm Function: Recent Progress

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (31 July 2024) | Viewed by 5070

Special Issue Editor


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Guest Editor
Department of Animal Biotechnology, Kyungpook National University, Daegu 37224, Republic of Korea
Interests: reproduction; reproductive toxicology; endocrine disruptor; biomarker; fertility; infertility; spermatozoa; spermatogenesis; pesticide
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

To date, various studies have been conducted on male reproductive function, particularly striving to elucidate the physiological functions of male germ cells. However, further efforts are still needed to achieve a complete understanding of the sperm function. Additionally, there is a need for additional efforts to elucidate the molecular mechanisms underlying normal sperm function, as well as the changes in sperm function that occur due to various environmental changes.

This Special Issue aims to cover the molecular mechanisms underlying general sperm function, as well as molecular-level mechanisms of sperm function in response to various environmental factors such as environmental pollution, age, exposure to various chemicals, etc. Reviews, original research articles, technical notes and commentaries related to all fields of studies on the recent progress in the molecular mechanisms underlying sperm function in mammals are welcome.

Dr. Woo-Sung Kwon
Guest Editor

Manuscript Submission Information

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Keywords

  • sperm
  • molecular mechanisms
  • sperm function
  • capacitation
  • signaling pathway
  • fertility
  • male reproduction

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Published Papers (1 paper)

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Review

17 pages, 614 KiB  
Review
Assessing the Risks of Pesticide Exposure: Implications for Endocrine Disruption and Male Fertility
by Claudine Uwamahoro, Jae-Hwan Jo, Seung-Ik Jang, Eun-Ju Jung, Woo-Jin Lee, Jeong-Won Bae and Woo-Sung Kwon
Int. J. Mol. Sci. 2024, 25(13), 6945; https://doi.org/10.3390/ijms25136945 - 25 Jun 2024
Cited by 11 | Viewed by 4630
Abstract
Pesticides serve as essential tools in agriculture and public health, aiding in pest control and disease management. However, their widespread use has prompted concerns regarding their adverse effects on humans and animals. This review offers a comprehensive examination of the toxicity profile of [...] Read more.
Pesticides serve as essential tools in agriculture and public health, aiding in pest control and disease management. However, their widespread use has prompted concerns regarding their adverse effects on humans and animals. This review offers a comprehensive examination of the toxicity profile of pesticides, focusing on their detrimental impacts on the nervous, hepatic, cardiac, and pulmonary systems, and their impact on reproductive functions. Additionally, it discusses how pesticides mimic hormones, thereby inducing dysfunction in the endocrine system. Pesticides disrupt the endocrine system, leading to neurological impairments, hepatocellular abnormalities, cardiac dysfunction, and respiratory issues. Furthermore, they also exert adverse effects on reproductive organs, disrupting hormone levels and causing reproductive dysfunction. Mechanistically, pesticides interfere with neurotransmitter function, enzyme activity, and hormone regulation. This review highlights the effects of pesticides on male reproduction, particularly sperm capacitation, the process wherein ejaculated sperm undergo physiological changes within the female reproductive tract, acquiring the ability to fertilize an oocyte. Pesticides have been reported to inhibit the morphological changes crucial for sperm capacitation, resulting in poor sperm capacitation and eventual male infertility. Understanding the toxic effects of pesticides is crucial for mitigating their impact on human and animal health, and in guiding future research endeavors. Full article
(This article belongs to the Special Issue Molecular Mechanisms Underlying Sperm Function: Recent Progress)
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