Molecular Mechanisms in Kidney Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 July 2025) | Viewed by 715
Special Issue Editor
Interests: cell culture; cholesterol metabolism; atherosclerosis; reactive oxygen species; signaling; endothelial cell biology; endothelial dysfunction; angiogenesis; vascular biology; vascular diseases; macrophage-foam cells; cardiovascular physiology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The kidneys play a vital role in maintaining overall health by regulating the excretion of waste products, salts, and water and performing several essential physiological functions. These include waste removal, reabsorption of critical nutrients, acid-base balance, electrolyte and water homeostasis, and hormone production. However, when kidney function declines to less than 15% due to acute or chronic insults, it can lead to a cascade of severe health complications, such as coagulation disorders, cardiovascular dysfunction, vascular calcification, cancer, and cognitive impairments. Persistent unresolved damage following acute or chronic kidney injury often results in maladaptive repair processes, which accelerate renal fibrosis. This progression is driven by disruptions in redox homeostasis, heightened inflammatory responses, and the senescence or death of renal tubular cells. Despite advances in nephrology, the cellular and molecular mechanisms underpinning the pathology of kidney diseases remain incompletely understood. Current treatments for kidney diseases are suboptimal, underscoring the urgent need to elucidate the mechanisms driving these conditions. A deeper understanding of these molecular and cellular pathways can pave the way for innovative therapeutic strategies to prevent and treat kidney diseases more effectively. To advance this goal, we invite researchers to contribute to the Special Issue titled "Molecular Mechanisms in Kidney Disease". This collection seeks to bring together original research articles and comprehensive reviews addressing the diverse aspects of kidney diseases. By fostering a platform for cutting-edge research, this Special Issue aspires to advance our understanding of kidney injury and repair mechanisms, ultimately improving patient outcomes.
Prof. Dr. Tzong-Shyuan Lee
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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Keywords
- kidney disease
- inflammation
- redox
- senescence
- cell death
- fibrosis
- signaling pathway
- uremic syndrome
- cardiorenal syndrome
- gut–kidney axis
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