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Supramolecular Chiral Self-Assembly and Applications

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Macromolecules".

Deadline for manuscript submissions: closed (31 May 2025) | Viewed by 401

Special Issue Editors


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Guest Editor
Dipartimento di Scienze Chimiche, Università degli Studi di Catania, Viale A. Doria 6, 95125 Catania, Italy
Interests: supramolecular chemistry related to porphyrin self-assembly and chirality; design of chiroptical probes for biomolecules conformations
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Guest Editor
Department of Chemical Science and Technology (STC), University of Rome “Tor Vergata”, 00133 Rome, Italy
Interests: porphyrinoid synthesis; chiral porphyrin aggregates; chiral materials; stereoselective sensors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

(Supra)molecular chirality is one of the most fundamental properties of nature and is important in different branches of science, technology, and medicine, relating to the ability of any object to exist as a pair of non-superimposable mirror images or to a unidirectional action (e.g., motion). It is widely seen and plays a key role in various self-assembled biological structures, such as saccharides, proteins, enzymes, membranes, DNA/RNA, etc. The phenomena of (supra)molecular chirality and chiral self-assembly are of paramount significance for all aspects of complex natural and artificial systems and include asymmetry generation, transfer, amplification, modulation, memorizing, and others upon non-covalent interactions. The investigation of these effects is a rapidly growing area of research and directly connects with numerous life processes, artificial systems, and modern industries. In addition, this research field has important practical applications in novel materials, enantioselective catalysis, chiral sensors, optical resolution, asymmetric synthesis, nanotechnology, medicine, pharmacology, biomimetic studies, and others.

The aim of this Special Issue is to highlight and overview all aspects of supramolecular chiral self-assembly and its applications in different natural/physical sciences and in modern technologies. All types of papers, including comprehensive reviews on general areas, mini reviews on specialized subjects, accounts of own research work, full experimental or theoretical papers, short communications, technical notes, comments, and others, are welcome for consideration.

Prof. Dr. Victor Borovkov
Prof. Dr. Alessandro D'Urso
Prof. Dr. Manuela Stefanelli
Guest Editors

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Keywords

  • (supra)molecular chirality
  • chiral self-assembly
  • enantioselective catalysis

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Published Papers (1 paper)

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Research

20 pages, 859 KiB  
Article
Theoretical Description of Changes in Conformation and Symmetry of Supramolecular Systems During the Reception of a Molecular Signal
by Yuriy Gorovoy, Natalia Rodionova, German Stepanov, Anastasia Petrova, Nadezda Penkova and Nikita Penkov
Int. J. Mol. Sci. 2025, 26(13), 6411; https://doi.org/10.3390/ijms26136411 - 3 Jul 2025
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Abstract
Aqueous solutions are not homogeneous and could be considered supramolecular systems. They can emit electromagnetic waves. Electromagnetic emission from one supramolecular system (“source”) can be received by another supramolecular system (“receiver”) without direct contact (distantly). This process represents a transfer of a “molecular [...] Read more.
Aqueous solutions are not homogeneous and could be considered supramolecular systems. They can emit electromagnetic waves. Electromagnetic emission from one supramolecular system (“source”) can be received by another supramolecular system (“receiver”) without direct contact (distantly). This process represents a transfer of a “molecular signal” and causes changes in conformation and symmetry of the “receiver”. The aim of the current work is to theoretically describe such changes primarily using a solution of the chiral protein interferon-gamma (IFNγ) as an example. We provide theoretical evidence that supramolecular systems of highly diluted (HD) aqueous solutions formed by self-assembly after mechanical activation generate a stronger molecular signal compared to non-activated solutions, due to their higher energy-saturated state. Additionally, molecular signals cause supramolecular systems with complex (including chiral) structures to undergo easier changes in conformation and symmetry compared to simpler systems, enhancing their biological activity. Using statistical physics, we obtained the parameter Ic, characterizing the magnitude of conformational and symmetry changes in supramolecular (including chiral) systems caused by molecular signals. In quantum information science, there is an analogue of the parameter Ic, which characterizes the entanglement depth of quantum systems. This study contributes to the understanding of the physico-chemical basis of distant molecular interactions and opens up new possibilities for controlling the properties of complex biological and chemical systems. Full article
(This article belongs to the Special Issue Supramolecular Chiral Self-Assembly and Applications)
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