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The Role of Magnesium and Other Bio-Elements in Health and Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 5121

Special Issue Editor


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Guest Editor
Jessenius Medical Faculty, Comenius University in Bratislava, Martin, Slovakia
Interests: molecular aspects of Mg2+ transports and cellular Mg homeostasis; SLC transporters; molecular genetics and physiology of neurodegeneration; rare mitochondrial diseases; phosphoproteome
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Special Issue Information

Dear Colleagues,

Magnesium (Mg) and other biometals (BM) play an essential role in various physiological processes in cells but also at the level of tissue, organ, and of the whole body. Aberrant homeostasis of Mg or other BM can be the consequence of some disease conditions, but it might also be a factor priming the onset of certain diseases. Among serious disease conditions associated with disturbed Mg and other BM homeostasis are cardiovascular, metabolic and also neurological, neurodegenerative, neuromuscular, and psychiatric diseases. In this Special Issue of IJMS, we welcome any original research, review or minireview/hypothesis regarding the role of Mg and of other BM (or their homeostatic factors) in the pathoetiology of human and animal ailments and their use in diagnostics and patient therapy following principles of translational and/or personalized medicine.

Dr. Martin Kolisek
Guest Editor

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Published Papers (1 paper)

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Review

38 pages, 4509 KiB  
Review
Selenium in Bodily Homeostasis: Hypothalamus, Hormones, and Highways of Communication
by Pamela Toh, Jessica L. Nicholson, Alyssa M. Vetter, Marla J. Berry and Daniel J. Torres
Int. J. Mol. Sci. 2022, 23(23), 15445; https://doi.org/10.3390/ijms232315445 - 06 Dec 2022
Cited by 16 | Viewed by 4811
Abstract
The ability of the body to maintain homeostasis requires constant communication between the brain and peripheral tissues. Different organs produce signals, often in the form of hormones, which are detected by the hypothalamus. In response, the hypothalamus alters its regulation of bodily processes, [...] Read more.
The ability of the body to maintain homeostasis requires constant communication between the brain and peripheral tissues. Different organs produce signals, often in the form of hormones, which are detected by the hypothalamus. In response, the hypothalamus alters its regulation of bodily processes, which is achieved through its own pathways of hormonal communication. The generation and transmission of the molecules involved in these bi-directional axes can be affected by redox balance. The essential trace element selenium is known to influence numerous physiological processes, including energy homeostasis, through its various redox functions. Selenium must be obtained through the diet and is used to synthesize selenoproteins, a family of proteins with mainly antioxidant functions. Alterations in selenium status have been correlated with homeostatic disturbances in humans and studies with animal models of selenoprotein dysfunction indicate a strong influence on energy balance. The relationship between selenium and energy metabolism is complicated, however, as selenium has been shown to participate in multiple levels of homeostatic communication. This review discusses the role of selenium in the various pathways of communication between the body and the brain that are essential for maintaining homeostasis. Full article
(This article belongs to the Special Issue The Role of Magnesium and Other Bio-Elements in Health and Disease)
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