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Mg2+ Transport and Mg Homeostasis: From Molecular Science to Clinical Praxis

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (29 November 2024) | Viewed by 4528

Special Issue Editor


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Guest Editor
Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 036 01 Martin, Slovakia
Interests: molecular aspects of Mg2+ transports and cellular Mg homeostasis; SLC transporters; molecular genetics and the physiology of neurodegeneration; rare mitochondrial diseases; phosphoproteome
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Special Issue Information

Dear Colleagues,

In the field of translational biomedicine, research on magnesium homeostasis in cells and the body has developed rapidly. We believe that it is now time to establish a new Special Issue that builds upon the previous Special Issue entitled “Mg2+ Transport and Mg Homeostasis: From Molecular Science to Clinical Praxis”. We welcome the contribution of any research that deepens our understanding of the regulation of Mg2+ transport into and out of cells. Studies that focus on the control of magnesium homeostasis in specific organs or the entire body under both healthy and pathological situations in humans will also be welcome. We also are particularly interested in the utilization of magnesium in treatment plans for common human illnesses such as diabetes mellitus, Alzheimer's disease, Parkinson’s disease, multiple sclerosis, ALS, neuromuscular disorders and cardiovascular disorders. We will also take into consideration manuscripts that concern the application of magnesium in the treatment of rare disorders and mitochondrial diseases. Lastly, in order to advance our understanding of magnesium's involvement in cellular and body biochemistry, we will gladly accept basic research papers that describe the involvement of magnesium in various biochemical (molecular) processes in cells and the body.

Dr. Martin Kolisek
Guest Editor

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Keywords

  • magnesium
  • Mg2+ transport
  • Mg homeostasis
  • Mg therapy
  • magnesiopathy
  • cellular energetics
  • biomedicine and translational medicine
  • human ailments
  • biochemistry
  • Mg in cellular regulation and signaling

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Published Papers (2 papers)

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Review

35 pages, 5608 KiB  
Review
The PACT Network: PRL, ARL, CNNM, and TRPM Proteins in Magnesium Transport and Disease
by Jeffery T. Jolly and Jessica S. Blackburn
Int. J. Mol. Sci. 2025, 26(4), 1528; https://doi.org/10.3390/ijms26041528 - 12 Feb 2025
Viewed by 1544
Abstract
Magnesium, the most abundant divalent metal within the cell, is essential for physiological function and critical in cellular signaling. To maintain cellular homeostasis, intracellular magnesium levels are tightly regulated, as dysregulation is linked to numerous diseases, including cancer, diabetes, cardiovascular disorders, and neurological [...] Read more.
Magnesium, the most abundant divalent metal within the cell, is essential for physiological function and critical in cellular signaling. To maintain cellular homeostasis, intracellular magnesium levels are tightly regulated, as dysregulation is linked to numerous diseases, including cancer, diabetes, cardiovascular disorders, and neurological conditions. Over the past two decades, extensive research on magnesium-regulating proteins has provided valuable insight into their pathogenic and therapeutic potential. This review explores an emerging mechanism of magnesium homeostasis involving proteins in the PRL (phosphatase of regenerating liver), ARL (ADP ribosylation factor-like GTPase family), CNNM (cyclin and cystathionine β-synthase domain magnesium transport mediator), and TRPM (transient receptor potential melastatin) families, collectively termed herein as the PACT network. While each PACT protein has been studied within its individual signaling and disease contexts, their interactions suggest a broader regulatory network with therapeutic potential. This review consolidates the current knowledge on the PACT proteins’ structure, function, and interactions and identifies research gaps to encourage future investigation. As the field of magnesium homeostasis continues to advance, understanding PACT protein interactions offers new opportunities for basic research and therapeutic development targeting magnesium-related disorders. Full article
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23 pages, 2070 KiB  
Review
The Role of Magnesium in Parkinson’s Disease: Status Quo and Implications for Future Research
by Michal Cibulka, Maria Brodnanova, Erika Halasova, Egon Kurca, Martin Kolisek and Milan Grofik
Int. J. Mol. Sci. 2024, 25(15), 8425; https://doi.org/10.3390/ijms25158425 - 1 Aug 2024
Cited by 1 | Viewed by 2554
Abstract
Neurodegenerative diseases represent an increasing economic, social, and, above all, medical burden worldwide. The second most prevalent disease in this category is Parkinson’s disease, surpassed only by Alzheimer’s. It is a treatable but still incurable systemic disease with a pathogenesis that has not [...] Read more.
Neurodegenerative diseases represent an increasing economic, social, and, above all, medical burden worldwide. The second most prevalent disease in this category is Parkinson’s disease, surpassed only by Alzheimer’s. It is a treatable but still incurable systemic disease with a pathogenesis that has not yet been elucidated. Several theories are currently being developed to explain the causes and progression of Parkinson’s disease. Magnesium is one of the essential macronutrients and is absolutely necessary for life as we know it. The magnesium cation performs several important functions in the cell in the context of energetic metabolism, substrate metabolism, cell signalling, and the regulation of the homeostasis of other ions. Several of these cellular processes have been simultaneously described as being disrupted in the development and progression of Parkinson’s disease. The relationship between magnesium homeostasis and the pathogenesis of Parkinson’s disease has received little scientific attention to date. The aim of this review is to summarise and critically evaluate the current state of knowledge on the possible role of magnesium in the pathogenesis of Parkinson’s disease and to outline possible future directions for research in this area. Full article
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