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Advancements in Inflammatory and Oxidative Disease Research

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Guest Editor
Laboratory for Systematic Investigations of Diseases, Department of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Marília 17525-902, SP, Brazil
Interests: inflammatory diseases; cardiovascular diseases; neurodegenerative diseases; inflammation; medicinal plants; oxidative stress
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Special Issue Information

Dear Colleagues,

Excessive inflammation and oxidative stress are detrimental to our body’s homeostasis. Therefore, we warmly invite you to submit your valuable contributions and papers to our Special Issue in the International Journal of Molecular Sciences. Inflammatory and oxidative diseases span a wide range of medical specialties, including endocrinology, neurology, gastroenterology, pulmonology, and rheumatology. Interdisciplinary research is especially relevant in diseases such as diabetes, which affect multiple organs beyond the pancreas, contributing to complications encompassing diabetic cardiomyopathy and diabetic nephropathy. Investigating novel approaches to inflammatory and oxidative diseases, disease progression, pharmacological prevention and intervention strategies is paramount. Our Special Issue welcomes original articles as well as reviews. We also invite you to submit studies on using medicinal plants and bioactive compounds as well as established, novel, or yet to be explored drugs as an intervention. Papers using interdisciplinary approaches to inflammatory and oxidative diseases are also welcome. Clinical human trials, preclinical cellular and animal studies, and special critical and systematic reviews with breakthrough advances will receive special attention.

This Special Issue is supervised by Dr. Sandra Barbalho and assisted by our Guest Editor Assistant Dr. Lucas Fornari Laurindo, Department of Biochemistry and Pharmacology, School of Medicine, Universidade de Marília (UNIMAR). Thank you for considering our Special Issue for your research. We appreciate your interest and look forward to receiving your papers.

Dr. Sandra Barbalho
Guest Editor

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Keywords

  • diabetes
  • cancer
  • neurological diseases
  • inflammation
  • oxidative stress
  • endocrinology
  • gastroenterology
  • pulmonology
  • rheumatology
  • cardiology
  • neurology
  • nephrology
  • dermatology

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Published Papers (1 paper)

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Review

19 pages, 1156 KB  
Review
The Pleiotropic Influence of Cannabidiol and Tetrahydrocannabinol on Inflammatory Biomarkers: A Systematic Review and Meta-Analytical Synthesis
by Bruno Moreira Candeloro, Camila M. de Oliveira, Fabiana Veronez Martelato Gimenez, Marianne P. C. N. Barbosa, Beatriz Paiva Soares, Ana C. F. Ruiz, Derfel R. M. A. Folegatti, Sandra Maria Barbalho, Nancy S. Oliveira, Andrey A. Porto, David Matthew Garner, Fernando H. Sousa and Vitor E. Valenti
Int. J. Mol. Sci. 2025, 26(23), 11618; https://doi.org/10.3390/ijms262311618 - 30 Nov 2025
Viewed by 280
Abstract
Preclinical data suggest that cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) modulate inflammatory pathways (e.g., NLRP3, NF-κB, and PPAR-γ), but clinical translation into consistent changes in circulating biomarkers remains ambiguous. Two reviewers independently screened the studies, extracted data, and assessed risk of bias with RoB-2. [...] Read more.
Preclinical data suggest that cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) modulate inflammatory pathways (e.g., NLRP3, NF-κB, and PPAR-γ), but clinical translation into consistent changes in circulating biomarkers remains ambiguous. Two reviewers independently screened the studies, extracted data, and assessed risk of bias with RoB-2. Random-effects meta-analyses (RevMan 5.4.1) formed standardized mean differences (SMD) or mean differences (MD) as appropriate. The certainty of evidence was graded by means of GRADE. Thirteen studies satisfied inclusion criteria; meta-analyses were feasible for IL-6 (four studies, n ≈ 129 per arm), IL-8 (two studies, n ≈ 78 per arm), IL-10 (two studies, n ≈ 92 per arm), and TNF-α (three studies, n ≈ 105 per arm). Pooled estimates favored CBD but were trivial and imprecise: IL-6 SMD −0.17 (95% CI −0.56 to 0.23; p = 0.41; I2 = 55%); IL-8 SMD −0.30 (95% CI −0.62 to 0.01; p = 0.06; I2 = 0%); IL-10 SMD −0.10 (95% CI −0.83 to 0.63; p = 0.79; I2 = 81%); and TNF-α SMD −0.09 (95% CI −0.45 to 0.27; p = 0.62; I2 = 33%). Individual trials reported reductions in biomarkers in high-exposure or diseased populations. GRADE ratings were as follows: IL-6 very low, IL-8 moderate, IL-10 low, and TNF-α moderate. Current RCT evidence demonstrates inconsistent, often trivial effects of phytocannabinoid interventions on circulating inflammatory biomarkers. Full article
(This article belongs to the Special Issue Advancements in Inflammatory and Oxidative Disease Research)
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