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Molecular Pathogenesis and Diagnostics of Lung Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 30 April 2024 | Viewed by 2715

Special Issue Editor


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Guest Editor
1. Instituto de Investigación Sanitaria Illes Balears (IdISBa), 07120 Palma de Mallorca, Spain
2. Centro de Investigación Biomédica en Red in Respiratory Diseases (CIBERES), 28029 Madrid, Spain
Interests: COPD; miRNAs; biomarker
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Special Issue Information

Dear Colleagues,

The study of the biological pathways underlying the pathogenesis of respiratory diseases (such as COPD, lung cancer, lung fibrosis, and asthma, among others) is one of the most relevant fields for biomedical research in respiratory medicine. This Special Issue aims to focus on the most recent advances and molecular discoveries of the pathways and processes involved in lung pathogenesis, which could serve as a basis for the development of potential therapies and diagnostic tools, such as predictor biomarkers (specially microRNAs and other molecules that can be found in liquid and tissue biopsies). Original research, as well as review articles, are welcome in this Special Issue, although cutting-edge methodologies might also be considered. The spread of such advances will provide the basis and standards for further research and the development of new diagnostic and therapeutic approaches.

Dr. Amanda Iglesias
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Published Papers (1 paper)

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Review

12 pages, 3644 KiB  
Review
Vascular Endothelial Growth Factor as Molecular Target for Bronchopulmonary Dysplasia Prevention in Very Low Birth Weight Infants
by Serafina Perrone, Sara Manti, Luca Buttarelli, Chiara Petrolini, Giovanni Boscarino, Laura Filonzi, Eloisa Gitto, Susanna Maria Roberta Esposito and Francesco Nonnis Marzano
Int. J. Mol. Sci. 2023, 24(3), 2729; https://doi.org/10.3390/ijms24032729 - 01 Feb 2023
Cited by 6 | Viewed by 2339
Abstract
Bronchopulmonary dysplasia (BPD) still represents an important burden of neonatal care. The definition of the disease is currently undergoing several revisions, and, to date, BPD is actually defined by its treatment rather than diagnostic or clinic criteria. BPD is associated with many prenatal [...] Read more.
Bronchopulmonary dysplasia (BPD) still represents an important burden of neonatal care. The definition of the disease is currently undergoing several revisions, and, to date, BPD is actually defined by its treatment rather than diagnostic or clinic criteria. BPD is associated with many prenatal and postnatal risk factors, such as maternal smoking, chorioamnionitis, intrauterine growth restriction (IUGR), patent ductus arteriosus (PDA), parenteral nutrition, sepsis, and mechanical ventilation. Various experimental models have shown how these factors cause distorted alveolar and vascular growth, as well as alterations in the composition and differentiation of the mesenchymal cells of a newborn’s lungs, demonstrating a multifactorial pathogenesis of the disease. In addition, inflammation and oxidative stress are the common denominators of the mechanisms that contribute to BPD development. Vascular endothelial growth factor-A (VEGFA) constitutes the most prominent and best studied candidate for vascular development. Animal models have confirmed the important regulatory roles of epithelial-expressed VEGF in lung development and function. This educational review aims to discuss the inflammatory pathways in BPD onset for preterm newborns, focusing on the role of VEGFA and providing a summary of current and emerging evidence. Full article
(This article belongs to the Special Issue Molecular Pathogenesis and Diagnostics of Lung Diseases)
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