Pneumonia and Sepsis: From Molecular Pathways to Translational Medicine

Dear Colleagues,

Sepsis and severe respiratory infections such as pneumonia represent two potentially life-threatening clinical conditions worldwide. Although these conditions could affect individuals of any age, it is well-recognized that the physiological age-related weakening of immune re-sponses is a crucial player in directing disease evolution towards negative outcomes. Regardless of the age of onset, both conditions are characterized by a deregulated hyperinflammatory re-sponse due to an overstimulation of the immune system. Despite the continuous progress in the medical field, these conditions still represent a great clinical challenge, deeply affecting healthcare and economic systems worldwide. Furthermore, both pneumonia and sepsis could display long-term effects, with a strong impact on survivors’ quality of life. In this scenario, the ability to identify early on the most at-risk patients and the quick identification of the best thera-peutic approach based on the individual patient’s clinical manifestations of the disease are of paramount importance and deserve constant consideration in the scientific community.

The aim of this Special Issue is to collect updated information about the molecular mechanisms involved in pneumonia and/or sepsis pathophysiology. Research papers dealing with novel bi-omarkers’ identification and validation, novel therapeutic target discovery, as well as the molec-ular basis of currently available or experimental therapeutic approaches are welcome to be sub-mitted to this Special Issue. Authors are welcome to submit their reviews and original articles.

Dr. Manuela Rizzi
Dr. Pier Paolo Sainaghi
Guest Editors

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