Heart Failure: New Paradigms in Molecular Pathology and Mechanistic Regulation
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 November 2026 | Viewed by 550
Special Issue Editors
2. Molecular and Clinical Medicine PhD Program, University of Palermo, 90133 Palermo, Italy
Interests: diabetic complications; cardiovascular diabetology; stroke pathogenesis; endothelial dysfunction
2. Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90127 Palermo, Italy
Interests: internal medicine; heart failure; arterial hypertension; cerebrovascular; cardiovascular diseases; systemic inflammation; vascular dysfunction
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Special Issue Information
Dear Colleagues,
Heart failure (HF) remains a major global health challenge, characterized by rising prevalence, substantial morbidity, and a persistently high socioeconomic burden. Despite significant progress in diagnostic tools and therapeutic strategies, the underlying molecular and immune mechanisms driving HF onset, progression, and organ–organ interactions are not fully understood. In particular, the complex interplay between systemic inflammation, immune dysregulation, cellular stress responses, metabolic pathways, and neurohormonal activation is increasingly recognized as a central determinant of disease trajectory.
Advances in multi-omics profiling, including transcriptomics, proteomics, and microRNA analyses, have opened new opportunities for characterizing HF phenotypes across the spectrum of reduced, mildly reduced, and preserved ejection fraction. Moreover, the emerging relevance of inter-organ communication—especially within the heart–kidney, heart–lung, and heart–brain axes—highlights the need for integrated, mechanistic research capable of bridging molecular biology with clinical outcomes.
This Special Issue, “Heart Failure: New Paradigms in Molecular Pathology and Mechanistic Regulation,” aims to gather high-quality original research and comprehensive reviews exploring novel molecular pathways, immune signatures, biomarkers, and therapeutic implications in HF. Contributions focusing on translational insights, precision-medicine strategies, and innovative experimental models are particularly welcome. Our goal is to advance current understanding and stimulate the development of new diagnostic and therapeutic approaches.
Dr. Carlo Domenico Maida
Dr. Mario Daidone
Guest Editors
Manuscript Submission Information
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Keywords
- heart failure
- molecular mechanisms
- immune regulation
- inflammation
- microRNA
- biomarkers
- cardio–renal axis
- translational medicine
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