Macrophages and Inflammation
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: closed (20 October 2025) | Viewed by 6586
Special Issue Editor
Interests: transcriptional, epigenetic, and metabolic programming of macrophages and their precoursors—corculating monocytes; tumor immunometabolism; macrophage biomarkers of therapy resistance; new molecular targets for TAM reprogramming in solid tumors
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Special Issue Information
Dear Colleagues,
Macrophages are ubiquitous in almost all human tissues and provide the first line of defense through acute inflammatory reactions induced by pathogens. At the same time, macrophages are key regulators of resolution of inflammation; they orchestrate healing and restore dynamic tissue homeostasis once the danger has been eliminated. The inability of macrophages to switch their programs from acute inflammation to its resolution and healing results in a chronic inflammatory status underlying major human disorders, like cancer and cardio-metabolic disorders. Another essential trigger of chronic inflammatory reactions are metabolic factors; for example, hyperglycemia and dyslipidemia, which are crucial for the development of diabetes and its vascular complications. Inflammatory macrophages also contribute to the development of neuro-inflammation and neurodegeneration by producing cytokines and through a reduction in tolerogenic clearance function.
Our issue is inviting submissions that address the mechanism of macrophage-mediated inflammation in infectious and sterile conditions. We also invite submissions that focus on the new intracellular pathways, which are critical for chronic inflammatory reactions, submissions dealing with molecule mechanisms, fixing the chronic inflammatory status of macrophages, and interfering with the phenotype switch for inflammation to healing and tolerance. We also invite submission that address the phenotypes, transcriptome, epigenetics and metabolomics of macrophages and their precursors - monocytes in human disorders where inflammation is an essential drive of pathology, including (but not restricted to) cardio-metabolic disorders, autoimmune disorders, and acute and chronic infectious disorders
Prof. Dr. Julia Kzhyshkowska
Guest Editor
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Keywords
- innate immunity
- transcriptional programs
- epigenetics
- immunometabolism
- receptors
- scavenging
- cytokines
- ROS
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