Tumor-Associated Macrophages: From Basic Research to Clinical Application
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Oncology".
Deadline for manuscript submissions: closed (1 May 2021) | Viewed by 3796
Special Issue Editor
Interests: transcriptional, epigenetic, and metabolic programming of macrophages and their precoursors—corculating monocytes; tumor immunometabolism; macrophage biomarkers of therapy resistance; new molecular targets for TAM reprogramming in solid tumors
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Special Issue Information
Dear Colleagues,
Tumor-associated macrophages (TAMs) are major innate immune cells in a tumor microenvironment and can constitute up to 50% of the mass of human tumors. TAMs are highly heterogeneous cells that originate from resident tissue-specific macrophages and from newly recruited monocytes. TAM variability strongly depends on cancer type, stage, and intratumoral heterogeneity. The majority of TAMs are programmed by TME to support primary tumor growth and metastatic spread. However, in some types of cancer, TAM can also restrict tumor growth and metastasis. TAM can also cooperate or interfere with anticancer therapy. There are three major mechanistic levels that define macrophages phenotype and functional polarization: transcriptional factors, epigenetic modifications, and metabolic pathways, and understanding the complexity of the interaction between thee pathways is the next challenge that will allow identifying pharmacological targets for immunomodulatory therapy in specific tumor types. The development of delivery systems for specific targeting for pro-tumoral TAMs in different types of cancer is the next task for biotechnology.
In the Special Issue, we invite submissions that describe fundamental aspects of TAM biology, interaction of TAM with cancer cells, and other cells in tumor microenvironment; novel preclinical models to decipher the function of TAM; association of TAM with various human cancers; new TAM biomarkers for the prediction of metastasis and therapy responses; therapeutic targets in TAM, and immunomodulatory therapeutic approaches based on targeting of TAM.
Prof. Dr. Julia Kzhyshkowska
Guest Editor
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Keywords
- tumor-associated macrophage
- cytokine
- transcriptional program
- signal transduction
- epigenetics
- phagocytosis
- biomarker
- cancer
- metastasis
- immunotherapy
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