Current Uses and Applications of Cyclodextrins
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Physical Chemistry and Chemical Physics".
Deadline for manuscript submissions: 20 May 2025 | Viewed by 5882
Special Issue Editors
Interests: chromatography; chiral separations; cyclodextrins; GC; SFC; CE
Interests: natural compounds; phytochemical analysis; sample preparation; gas chromatography; HPLC; ionic liquids; deep eutectic solvents; chiral analysis
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Special Issue Information
Dear Colleagues,
In recent years, chiral separations have become increasingly important, where cyclodextrins play crucial roles. Cyclodextrins are cyclic oligosaccharide molecules, which contain six, seven, or eight D(+)-glucopyranose units, assigned by Greek letters α, β, and γ, respectively. The cyclodextrins can encapsulate suitable substances in their apolar cavities, forming noncovalent host–guest inclusion complexes. The internal cavities of cyclodextrins provide protection against the evaporation, oxidation, light-induced decomposition of sensitive guest substances. Cyclodextrin inclusion complexes have been used as controlled release formulation devices for a long time.
One of the most widely used applications of cyclodextrins relates to their utilization as chiral selectors. They have several chiral centres, with five in every glucose unit. The chemical modifications of hydroxyl groups of cyclodextrins (i.e., acyl, alkyl, hydroxyalkyl, carboxyalkyl, suphoalkyl, and phosphate, etc.) provide further chiral recognition properties with their interactions. The chiral recognition properties of a cyclodextrin depend on the size, geometry, and chemical characters of its cavity. Chemically modified cyclodextrins have flexible structures, enabling enantioseparations via an induced fit. Several chiral centres, various interaction abilities, and the induced fit of derivatized cyclodextrins demonstrate the chiral recognitions across a broad spectrum of enantiomers.
The majority of chiral separations have been used with cyclodextrin selectors in gas chromatography and capillary electrophoresis. The cyclodextrins have also been frequently used for chiral separation in HPLC, SFC, and membrane separations.
This Special Issue provides a comprehensive updated overview on the usefulness of cyclodextrins as chiral selectors.
Prof. Dr. Zoltan Juvancz
Dr. Cecilia Cagliero
Guest Editors
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Keywords
- cyclodextrins
- chiral separations
- GC, HPLC, SFC, and CE
- chiral recognition mechanisms
- structure–chiral selectivity relationships
- a combination of chromatographic and structure determination methods (e.g., MS, NMR, CD, etc.)
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