Mechanism and Role of Adipokines in Cancer

Dear Colleagues,

This Special Issue is dedicated to exploring the multifaceted challenges and promising opportunities in the field of cancer research, diagnosis, and treatment. This Special Issue seeks to bring together insights from researchers, clinicians, and geneticists to address critical aspects such as early detection, personalized medicine, treatment resistance, survivorship, and disparities in care. Recent studies have focused on the role of adipokines, hormones that are secreted by the adipose tissue, on oncogenesis that, in an obesity state, can act directly on metabolic pathways such as the Janus kinase–signal transducer and activator of transcription (JAK-STAT) or phosphoinositide 3-kinase (PI3K) pathways, or via tumor microenvironment alteration. In the tumor microenvironment, noncancer cells such as adipocytes and macrophages interact to amplify inflammation and disrupt the balance of adipocytokine production. Consequently, these events culminate in a cascade of consequences, including the reprogramming of cancer cell metabolism, facilitation of tumor invasion and metastasis, and disruption of immune clearance mechanisms.

Led by Dr. Maria-Ioanna Argentou, Prof. Eleni Papadaki-Petrou, and Dr. Fotinos-Ioannis D. Dimitrakopoulos, and assisted by our Topical Advisory Panel Member Dr. Konstantina Soultana Kitsou (Department of Surgery, University Hospital of Patras), this Special Issue welcomes contributions spanning basic science discoveries, clinical trials, and translational research. We aim to advance our understanding of the mechanism and role of adipokines in cancer, develop effective prevention and treatment strategies, and ultimately improve outcomes and quality of life for patients and survivors.

Dr. Maria Ioanna Argentou
Prof. Dr. Helen Papadaki-Petrou
Dr. Foteinos-Ioannis Dimitrakopoulos
Guest Editors

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• adipokines
• adipose tissue
• tumorigenesis
• tumor microenvironment
• cancer biomarkers
• obesity
• chemerin
• leptin
• adiponectin