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Recent Advances in Applied Bioinorganic Chemistry

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (20 December 2024) | Viewed by 3657

Special Issue Editors


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Guest Editor
Section of Inorganic and Analytical Chemistry, Department of Chemistry, University of Ioannina, 451 10 Ioannina, Greece
Interests: biological inorganic chemistry; discovery and development of new therapeutic anticancer or antibacterial formulation; drugs activation (anti-inflammatory drugs (NSAIDs), antibiotics or antithyroid) with main group elements; structure activity relationship (SAR); intracellular components (DNA-Enzymes-Mitochondrion) interaction of with drugs or new formulations; in vitro cells’ and microbes’ screening; in vivo testing of the toxicity and genotoxicity; study of the molecular mechanism of action; activation of apoptosis mechanism; enzymes inhibitory study; encapsulated formulations into micelles, hydrogels or natural resins with enhanced bioactivity; active medical devices (anti-microbial conduct lens, medical gauzes for wound healing, active antimicrobial packages for medical usage, etc); anti-thyroid drugs mechanism of action ex vivo
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Special Issue Information

Dear Colleagues,

This Special Issue of the journal IJMS entitled “Recent Advances in Applied Bioinorganic Chemistry" will cover a selection of recent research and review articles in the field. Bioinorganic Chemistry has important applications in various areas, including catalysis, energy, and medicine. More specifically, the applications of Bioinorganic Chemistry include (i) drug design and development (cancer, Alzheimer's, HIV, etc.); (ii) catalysis (metalloenzymes, etc.); (iii) materials science (biomimetic materials, sensing, drug delivery, etc.); (iv) environmental science; (v) agriculture (fertilizers, pesticides, etc.); (vi) forensics (spectroscopic and analytical techniques); (vii) imaging: (MRI, XAS, etc.); (viii) biotechnology (biosensors, etc.); (ix) energy conversion.

The issue will feature original research articles, reviews, and perspectives. Moreover, the research in this field brings together stakeholders from different disciplines, such as chemists, biologists, pharmacists, etc. The readers of this Special Issue will gain an appreciation of the evolution of applications in bioinorganic chemistry.

Dr. Christina N. Banti
Prof. Dr. Sotiris K Hadjikakou
Guest Editors

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Keywords

  • applied bioinorganic chemistry in drug design and development
  • applied bioinorganic chemistry in catalysis
  • applied bioinorganic chemistry in materials science
  • applied bioinorganic chemistry in environmental science
  • applied bioinorganic chemistry in forensics
  • applied bioinorganic chemistry in imaging
  • applied bioinorganic chemistry in biotechnology
  • applied bioinorganic chemistry in agriculture
  • applied bioinorganic chemistry in energy conversion

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Published Papers (2 papers)

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Research

23 pages, 3137 KiB  
Article
Manganese(II) Complexes with Non-Steroidal Anti-Inflammatory Drugs: Structure and Biological Activity
by Filitsa Dimiza, Antonios G. Hatzidimitriou and George Psomas
Int. J. Mol. Sci. 2024, 25(24), 13457; https://doi.org/10.3390/ijms252413457 - 16 Dec 2024
Viewed by 929
Abstract
Nine manganese(II) complexes with a series of non-steroidal anti-inflammatory drugs (namely sodium diclofenac, diflunisal, flufenamic acid, sodium meclofenamate, mefenamic acid, and tolfenamic acid) were prepared in the presence of diverse nitrogen donors, i.e., pyridine, 1,10–phenanthroline, 2,2′–bipyridine and neocuproine, as co-ligands and were characterized [...] Read more.
Nine manganese(II) complexes with a series of non-steroidal anti-inflammatory drugs (namely sodium diclofenac, diflunisal, flufenamic acid, sodium meclofenamate, mefenamic acid, and tolfenamic acid) were prepared in the presence of diverse nitrogen donors, i.e., pyridine, 1,10–phenanthroline, 2,2′–bipyridine and neocuproine, as co-ligands and were characterized with spectroscopic techniques and single-crystal X-ray crystallography. The biological profile of the resultant complexes was investigated regarding their antioxidant potency and their interaction with DNA and serum albumins. The complexes interact with calf–thymus DNA in an intercalative mode and bind tightly and reversibly to human and bovine serum albumins studied. In order to assess the antioxidant activity of the Mn(II) complexes, their ability to scavenge 2,2′–azinobis(3–ethylbenzothiazoline–6–sulfonic acid) free radicals was monitored. Full article
(This article belongs to the Special Issue Recent Advances in Applied Bioinorganic Chemistry)
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15 pages, 3332 KiB  
Article
Non-Steroidal Anti-Inflammatory Drugs Loaded to Micelles for the Modulation of Their Water Solubility
by Christina N. Banti, Angelos G. Kalampounias and Sotiris K. Hadjikakou
Int. J. Mol. Sci. 2023, 24(20), 15152; https://doi.org/10.3390/ijms242015152 - 13 Oct 2023
Cited by 2 | Viewed by 1666
Abstract
The low water solubility of aspirin (ASPH) is well known, creating research challenges regarding both its composition and its delivery. Therefore, the development of new aspirin-based formulations that are water soluble is a research, technological, and financial issue. With the aim to improve [...] Read more.
The low water solubility of aspirin (ASPH) is well known, creating research challenges regarding both its composition and its delivery. Therefore, the development of new aspirin-based formulations that are water soluble is a research, technological, and financial issue. With the aim to improve the water solubility of ASPH, the micelle of formula SLS@ASPH (SLS = Sodium Lauryl Sulfate) was formed. The Critical Micelle Concentration (CMC) of SLS in the presence of ASPH was determined by ultrasonic velocity, complementary, and transient birefringence measurements. The SLS@ASPH was characterized by the melting point (m.p.), attenuated total reflection spectroscopy (FT-IR-ATR), and X-ray fluorescence spectroscopy (XRF) in a solid state and in a solution by ultraviolet-visible (UV-Vis) and 1H NMR spectroscopies. The SLS/ASPH molar ratio was determined to be 5/1 in SLS@ASPH. The inhibitory activity of SLS@ASPH towards lipoxygenase (LOX), an enzyme that takes part in the inflammation mechanism, was studied. The inhibitory activity of SLS@ASPH against LOX is 3.5-fold stronger than that of free SLS. The in vitro toxicity of the SLS@ASPH was tested on immortalized human keratinocyte (HaCaT) cells. Full article
(This article belongs to the Special Issue Recent Advances in Applied Bioinorganic Chemistry)
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