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Antibiotics
Special Issues
Silver and Gold Compounds as Antibiotics, 2nd Edition
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Silver and Gold Compounds as Antibiotics, 2nd Edition

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Mechanisms and Structural Biology of Antibiotic Action".

Deadline for manuscript submissions: closed (15 January 2025) | Viewed by 5036

Special Issue Editors

Prof. Dr. Sotiris K Hadjikakou

E-Mail Website
Guest Editor
Section of Inorganic and Analytical Chemistry, Department of Chemistry, University of Ioannina, 451 10 Ioannina, Greece
Interests: biological inorganic chemistry; discovery and development of new therapeutic anticancer or antibacterial formulation; drugs activation (anti-inflammatory drugs (NSAIDs), antibiotics or antithyroid) with main group elements; structure activity relationship (SAR); intracellular components (DNA-Enzymes-Mitochondrion) interaction of with drugs or new formulations; in vitro cells’ and microbes’ screening; in vivo testing of the toxicity and genotoxicity; study of the molecular mechanism of action; activation of apoptosis mechanism; enzymes inhibitory study; encapsulated formulations into micelles, hydrogels or natural resins with enhanced bioactivity; active medical devices (anti-microbial conduct lens, medical gauzes for wound healing, active antimicrobial packages for medical usage, etc); anti-thyroid drugs mechanism of action ex vivo
Special Issues, Collections and Topics in MDPI journals
Dr. Christina N. Banti

E-Mail Website
Guest Editor
Section of Inorganic and Analytical Chemistry, Department of Chemistry, University of Ioannina, 451 10 Ioannina, Greece
Interests: biological inorganic chemistry; anticancer metallodrugs; antibacterial metallodrugs
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The inaugural volume of the Special Issue, "Silver and Gold Compounds as Antibiotics," featured ten papers. Encouraged by the response from scientists in the field, we are now launching a second volume centered on the same theme.

Following the path established by the initial volume, this second edition will highlight recent research and review articles within biological inorganic chemistry. Specifically, it will explore the antimicrobial properties of silver and gold compounds, encompassing their nanoparticles.

This second volume aims to provide a comprehensive perspective on this evolving field, presenting recent breakthroughs and the most current research. The focus will remain on the role of silver or gold compounds and their nanoparticles as antibiotics. Readers engaging with this Special Issue will acquire an extensive understanding of antimicrobial metal compounds.

Prof. Dr. Sotiris K Hadjikakou
Dr. Christina N. Banti
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bio-inorganic chemistry
  • metal compounds
  • antimicrobial drugs
  • antibiotics
  • medical applications
  • antimicrobial resistance

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

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13 pages, 3364 KiB  
Article
Synergistic Antimicrobial Activity of Biogenic Silver Nanoparticles and Acanthospermum australe Essential Oil against Skin Infection Pathogens
by Javier Mussin and Gustavo Giusiano
Antibiotics 2024, 13(7), 674; https://doi.org/10.3390/antibiotics13070674 - 20 Jul 2024
Cited by 2 | Viewed by 1545
Abstract
In response to the steady increase in antimicrobial-resistant strains, the World Health Organisation has emphasised the need to investigate new antimicrobial agents and alternative therapies that improve the spectrum of activity and reduce the dose required, thus improving safety. This study focused on [...] Read more.
In response to the steady increase in antimicrobial-resistant strains, the World Health Organisation has emphasised the need to investigate new antimicrobial agents and alternative therapies that improve the spectrum of activity and reduce the dose required, thus improving safety. This study focused on the characterisation of Acanthospermum australe essential oil and green-synthesis silver nanoparticles (AgNP), evaluating their cytotoxicity in human cells, antimicrobial activity and synergistic effect against pathogens causing skin infections. The main components of the essential oil were germacrene A (24.07%), γ-cadinene (21.47%) and trans-caryophyllene (14.97%). Spherical AgNP with a diameter of 15 ± 3 nm were synthesised. The essential oil showed antimicrobial activity against dermatophytes and Malassezia globosa, while AgNP were found to be active against bacteria, yeasts and dermatophytes. Both compounds were found to be primarily non-cytotoxic at the concentrations required to inhibit microbial growth. Furthermore, the combined use of essential oil and AgNP showed a synergistic antimicrobial effect against dermatophytes and M. globosa. In conclusion, the results suggest that the combined use of bioactive compounds from natural sources, such as essential oil and biogenic AgNP, has the potential to improve antimicrobial efficacy against specific skin pathogens, particularly Microsporum canis, Nannizzia gypsea and M. globosa. Full article
(This article belongs to the Special Issue Silver and Gold Compounds as Antibiotics, 2nd Edition)
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13 pages, 17585 KiB  
Article
Combinations of Cannabinoids with Silver Salts or Silver Nanoparticles for Synergistic Antibiotic Effects against Methicillin-Resistant Staphylococcus aureus
by John Jackson, Ali Shademani, Manisha Dosanjh, Claudia Dietrich, Mark Pryjma, Dana M. Lambert and Charles J. Thompson
Antibiotics 2024, 13(6), 473; https://doi.org/10.3390/antibiotics13060473 - 22 May 2024
Cited by 3 | Viewed by 2024
Abstract
Silver has been shown to improve the antibiotic effects of other drugs against both Gram- positive and -negative bacteria. In this study, we investigated the antibiotic potential of cannabidiol (CBD), cannabichromene (CBC) and cannabigerol (CBG) and their acidic counterparts (CBDA, CBCA, CBGA) against [...] Read more.
Silver has been shown to improve the antibiotic effects of other drugs against both Gram- positive and -negative bacteria. In this study, we investigated the antibiotic potential of cannabidiol (CBD), cannabichromene (CBC) and cannabigerol (CBG) and their acidic counterparts (CBDA, CBCA, CBGA) against Gram-positive bacteria and further explored the additive or synergistic effects of silver nitrate or silver nanoparticles using 96-well plate growth assays and viability (CFUs- colony-forming units). All six cannabinoids had strong antibiotic effects against MRSA with minimal inhibitory concentrations (MICs) of 2 mg/L for CBG, CBD and CBCA; 4 mg/L for CBGA; and 8 mg/L for CBC and CBDA. Using 96-well checkerboard assays, CBC, CBG and CBGA showed full or partial synergy with silver nitrate; CBC, CBDA and CBGA were fully synergistic with silver nanoparticles against MRSA. Using CFU assays, combinations of CBC, CBGA and CBG with either silver nitrate or silver nanoparticles, all at half or quarter MICs, demonstrated strong, time-dependent inhibition of bacterial growth (silver nitrate) and bactericidal effects (silver nanoparticles). These data will lead to further investigation into possible biomedical applications of specific cannabinoids in combination with silver salts or nanoparticles against drug-resistant Gram-positive bacteria. Full article
(This article belongs to the Special Issue Silver and Gold Compounds as Antibiotics, 2nd Edition)
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Review

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29 pages, 1990 KiB  
Review
Silver Nanoparticles: A Versatile Tool Against Infectious and Non-Infectious Diseases
by Sara González-Fernández, Noelia Blanco-Agudín, David Rodríguez, Iván Fernández-Vega, Jesús Merayo-Lloves and Luis M. Quirós
Antibiotics 2025, 14(3), 289; https://doi.org/10.3390/antibiotics14030289 - 11 Mar 2025
Viewed by 861
Abstract
Silver nanoparticles possess remarkable properties that render them highly beneficial for medical applications in both infectious and non-infectious diseases. Among their most renowned attributes is their antimicrobial activity. They have demonstrated efficacy against a wide range of bacteria, fungi, protozoa, and viruses. Additionally, [...] Read more.
Silver nanoparticles possess remarkable properties that render them highly beneficial for medical applications in both infectious and non-infectious diseases. Among their most renowned attributes is their antimicrobial activity. They have demonstrated efficacy against a wide range of bacteria, fungi, protozoa, and viruses. Additionally, the antitumor and anti-diabetic properties of silver nanoparticles, along with their ability to promote wound healing and their application as biosensors, underscore their therapeutic potential for various non-infectious conditions. As silver nanoparticles are employed for medical purposes, their potential toxicity must be considered. While silver nanoparticles present a promising alternative in the therapeutic domain, further research is needed to elucidate their precise mechanisms of action, optimize their efficacy, and mitigate any potential health risks associated with their use. Full article
(This article belongs to the Special Issue Silver and Gold Compounds as Antibiotics, 2nd Edition)
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