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Mesenchymal Stem/Stromal Cells and Hematological Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 180

Special Issue Editors

Laboratory for Physiology of Hematopoiesis, National Medical Research Center for Hematology, Noviy Zykovskiy pr., 4, 125167 Moscow, Russia
Interests: hematopoietic and mesenchymal stem cells; leukemia; stromal microenvironment

Special Issue Information

Dear Colleagues,

In recent years, it has been convincingly demonstrated that the quality of hematopoiesis depends on the stromal microenvironment of the bone marrow. This microenvironment has a complex composition and includes endothelial cells, mesenchymal stem/stromal cells, osteolineage cells, perivascular cells, adipocytes, macrophages, the sympathetic nervous system, CXCL12 abundant reticular cells, extracellular matrix, cykines, and chemokines. Mesenchymal stem/stromal cells (MSCs) and their descendants play a central role in maintaining normal hematopoiesis. In leukemia, the stromal microenvironment is severely damaged both due to tumor cells and subsequent chemotherapy. The role of MSCs in leukemia and other hematological diseases has not been sufficiently studied. Additional knowledge will allow us to identify targets for the restoration and maintenance of hematopoiesis in patients using, among other interventions, elements of the stromal microenvironment. The purpose of this Special Issue is to bring together research/review articles describing recent results on the role of mesenchymal stem/stromal cells in hematological diseases, including leukemogenesis and possible microenvironment targets for treatment.

Dr. Nina Drize
Dr. Alexander V. Belyavsky
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • stromal microenvironment
  • mesenchymal stem/stromal cells
  • acute leukemia
  • chronic leukemia
  • chemotherapy
  • stem cell transplantation
  • regeneration

Published Papers

This special issue is now open for submission.
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